Discovery of Subcellular-Targeted Aza-BODIPY Photosensitizers for Efficient Photodynamic Antitumor Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01653
Abstract: In this study, we linked classical organelle-targeting groups, such as triphenylphosphonium, pentafluorobenzene, and morpholine, to our previously reported potent monoiodo Aza-BODIPY photosensitizer (BDP-15). They were conveniently prepared and retained the advantages of Aza-BODIPY PS with… read more here.
Keywords: discovery subcellular; subcellular targeted; antitumor; targeting groups ... See more keywords
Optimizing mitochondrial-targeting groups of positively-charged BODIPY nanoparticles for enhanced photodynamic therapy
Sign Up to like & getrecommendations! Published in 2024 at "Materials Chemistry Frontiers"
DOI: 10.1039/d4qm00725e
Abstract: Mitochondria play an important role in regulating programmed cell death and various available mitochondrial-targeting photosensitizers are modified by cationic groups, especially triphenylphosphine (TPP). However, it’s still a big challenge to... read more here.
Keywords: groups positively; optimizing mitochondrial; charged bodipy; mitochondrial targeting ... See more keywords