Targeting the Hedgehog signalling pathway in triple negative breast cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e24216
Abstract: e24216Background: Paracrine Hedgehog (Hh) signalling occurs in ~30% of all triple negative breast cancers (TNBCs) and confers worse overall survival. The tumour stroma has been shown to facilitate ... read more here.
Keywords: hedgehog signalling; negative breast; targeting hedgehog; triple negative ... See more keywords
Combined targeting of HEDGEHOG signaling and BRD4 as a novel therapeutic option against melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Oncotarget"
DOI: 10.18632/oncotarget.28441
Abstract: The Hedgehog-GLI (HH/GLI) pathway is aberrantly activated in several types of cancer. Canonical HH/ GLI pathway is triggered by binding of HH ligands to the twelve-pass transmembrane receptor Patched 1 (PTCH1), which retrieves its inhibition… read more here.
Keywords: hedgehog signaling; hedgehog; targeting hedgehog; gli ... See more keywords
Targeting the Hedgehog Pathway in Rhabdomyosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15030727
Abstract: Simple Summary In the first sections of this review, we provide a comprehensive description of the Hedgehog signalling pathway in mammals and the main general models of pathway activation. Subsequently, the review focuses on the… read more here.
Keywords: hedgehog pathway; targeting hedgehog; smo inhibitors; pathway rhabdomyosarcoma ... See more keywords