LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "targeting host" as a keyword



Targeting host lipid flows: Exploring new antiviral and antibiotic strategies

Sign Up to like & get
recommendations! Published in 2019 at "Cellular Microbiology"

DOI: 10.1111/cmi.12996

Abstract: Bacteria and viruses pose serious challenges for humans because they evolve continuously. Despite ongoing efforts, antiviral drugs to treat many of the most troubling viruses have not been approved yet. The recent launch of new… read more here.

Keywords: antiviral antibiotic; flows exploring; lipid flows; host ... See more keywords

Targeting host tyrosine kinase receptor EphA2 signaling via small-molecule ALW-II-41-27 inhibits macrophage pro-inflammatory signaling responses to Pneumocystis carinii β-glucans

Sign Up to like & get
recommendations! Published in 2024 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00811-23

Abstract: ABSTRACT Pneumocystis jirovecii, the fungus that causes Pneumocystis jirovecii pneumonia (PJP), is a leading cause of morbidity and mortality in immunocompromised individuals. We have previously shown that lung epithelial cells can bind Pneumocystis spp. β-glucans… read more here.

Keywords: receptor; inflammatory signaling; targeting host; epha2 receptor ... See more keywords

Targeting IL-13 as a Host-Directed Therapy Against Ulcerative Colitis

Sign Up to like & get
recommendations! Published in 2018 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2018.00395

Abstract: The role of interleukin-13 in mediating ulcerative colitis remains under scrutiny. Compelling evidence from both man and mouse suggests that IL-13 not only contributes to the pathology associated with disease but is also involved in… read more here.

Keywords: directed therapy; therapy ulcerative; host directed; colitis ... See more keywords

Host proteases: key regulators in viral infection and therapeutic targeting

Sign Up to like & get
recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1671173

Abstract: Viral infections pose a major threat to global health, causing severe pneumonia, meningitis, hepatitis, and fatal complications. Viruses are highly dependent on host cellular factors to complete their life cycle, and host proteases, as one… read more here.

Keywords: host proteases; broad spectrum; host; targeting host ... See more keywords

Targeting the Host Mitochondria as a Novel Human Cytomegalovirus Antiviral Strategy

Sign Up to like & get
recommendations! Published in 2023 at "Viruses"

DOI: 10.3390/v15051083

Abstract: Human cytomegalovirus (HCMV) exploits host mitochondrial function to promote viral replication. HCMV gene products have been described to directly interact and alter functional or structural aspects of host mitochondria. Current antivirals against HCMV, such as… read more here.

Keywords: mitochondrial function; host mitochondrial; targeting host; human cytomegalovirus ... See more keywords