Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2068488
Abstract: ABSTRACT Interferon gamma (IFNG/IFNγ)-induced adaptive immune resistance remains a challenge for tumor therapy. We observed that the chaperone heat shock protein 90 (HSP90) stabilizes the transcription factor signal transducer and activator of transcription 1 (STAT1),… read more here.
Keywords: hsp90; pancreas carcinoma; targeting hsp90; hsp90 sensitizes ... See more keywords
Dual targeting of Hsp90 in childhood acute lymphoblastic leukaemia
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DOI: 10.1111/bjh.14275
Abstract: Survival rates for children with acute lymphoblastic leukaemia (ALL) have improved considerably to over 90% in recent years but despite these advances, 15–20% of patients relapse. Current chemotherapeutic regimens are designed around the properties of… read more here.
Keywords: hsp90; lymphoblastic leukaemia; celastrol; targeting hsp90 ... See more keywords
Targeting Hsp90-Cdc37: A Promising Therapeutic Strategy by Inhibiting Hsp90 Chaperone Function.
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DOI: 10.2174/1389450117666160527125522
Abstract: BACKGROUND & OBJECTIVE The Hsp90 chaperone protein regulates the folding, maturation and stability of a wide variety of oncoproteins. In recent years, many Hsp90 inhibitors have entered into the clinical trials while all of them… read more here.
Keywords: hsp90 chaperone; hsp90; targeting hsp90; hsp90 cdc37 ... See more keywords
Targeting HSP90 Inhibits Proliferation and Induces Apoptosis Through AKT1/ERK Pathway in Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.724192
Abstract: Lung cancer is one of the most common malignant cancers worldwide. Searching for specific cancer targets and developing efficient therapies with lower toxicity is urgently needed. HPS90 is a key chaperon protein that has multiple… read more here.
Keywords: akt1 erk; lung cancer; targeting hsp90; cancer ... See more keywords