Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.07.013
Abstract: Cancer elimination in humans can be achieved with immunotherapy that relies on T lymphocyte-mediated recognition of tumor antigens. Several types of these antigens have been recognized based on their cellular origins and expression patterns, while… read more here.
Keywords: immunotherapy; tumor antigens; identifying targeting; human tumor ... See more keywords
Sam68 Allows Selective Targeting of Human Cancer Stem Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.05.026
Abstract: Targeting of human cancer stem cells (CSCs) requires the identification of vulnerabilities unique to CSCs versus healthy resident stem cells (SCs). Unfortunately, dysregulated pathways that support transformed CSCs, such as Wnt/β-catenin signaling, are also critical… read more here.
Keywords: cancer stem; human cancer; targeting human; stem ... See more keywords
Rational Design for Optimizing Hybrid Thermo-triboelectric Generators Targeting Human Activities
Sign Up to like & getrecommendations! Published in 2019 at "ACS Energy Letters"
DOI: 10.1021/acsenergylett.9b01426
Abstract: Despite the rise in Internet of Things devices and mobile electronics, devising an energy harvester with sufficient time-averaged power remains a challenge when targeting human activities. Here, we... read more here.
Keywords: hybrid thermo; optimizing hybrid; rational design; human activities ... See more keywords
Targeting human langerin promotes HIV-1 specific humoral immune responses
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009749
Abstract: The main avenue for the development of an HIV-1 vaccine remains the induction of protective antibodies. A rationale approach is to target antigen to specific receptors on dendritic cells (DC) via fused monoclonal antibodies (mAb).… read more here.
Keywords: specific humoral; human langerin; tfh cells; targeting human ... See more keywords
Targeting Human Herpesviruses: An Effective Strategy for Treating Idiopathic Pulmonary Fibrosis?
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the American Thoracic Society"
DOI: 10.1513/annalsats.202105-536ed
Abstract: Targeting Human Herpesviruses: An Effective Strategy for Treating Idiopathic Pulmonary Fibrosis? Toby M. Maher, M.D., M.Sc., Ph.D. Hastings Center for Pulmonary Research and Division of Pulmonary, Critical Care and SleepMedicine, Keck School of Medicine, University… read more here.
Keywords: effective strategy; treating idiopathic; strategy treating; human herpesviruses ... See more keywords
Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202152904
Abstract: Calreticulin (CALR) is recurrently mutated in myelofibrosis via a frameshift that removes an endoplasmic reticulum retention signal, creating a neoepitope potentially targetable by immunotherapeutic approaches. We developed a specific rat monoclonal IgG2α antibody, 4D7, directed… read more here.
Keywords: targeting human; calr; human calr; mutant calr ... See more keywords
Targeting Human Papillomavirus-Associated Cancer by Oncoprotein-Specific Recombinant Antibodies
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22179143
Abstract: In recent decades, recombinant antibodies against specific antigens have shown great promise for the therapy of infectious diseases and cancer. Human papillomaviruses (HPVs) are involved in the development of around 5% of all human cancers… read more here.
Keywords: papillomavirus associated; human papillomavirus; cancer; targeting human ... See more keywords
Targeting Human Proteins for Antiviral Drug Discovery and Repurposing Efforts: A Focus on Protein Kinases
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15020568
Abstract: Despite the great technological and medical advances in fighting viral diseases, new therapies for most of them are still lacking, and existing antivirals suffer from major limitations regarding drug resistance and a limited spectrum of… read more here.
Keywords: targeting human; drug discovery; antiviral drug; host ... See more keywords