Targeting IDH1 and IDH2 Mutations in Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Current Hematologic Malignancy Reports"
DOI: 10.1007/s11899-017-0418-6
Abstract: Purpose of ReviewOver the past decade, the pathogenic role of mutations in isocitrate dehydrogenases (IDH) 1 and 2, affecting approximately 20% of patients with AML, has been defined, allowing for the development of specific therapeutic… read more here.
Keywords: mutations acute; idh1 idh2; idh2 mutations; myeloid leukemia ... See more keywords
Abstract LB-B05: Targeting IDH1 inhibits survival and growth of pancreatic cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-lb-b05
Abstract: Pancreatic ductal adenocarcinoma (PDA) cells have elevated levels of reactive oxygen species (ROS) compared to adjacent normal cells. Although ROS play a role in pancreatic carcinogenesis, the accumulation of excess ROS at later stages of… read more here.
Keywords: targeting idh1; inhibits survival; survival growth; pda cells ... See more keywords