Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage
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DOI: 10.1016/j.tranon.2021.101159
Abstract: Highlights • GILT is upregulated in chemoresistant LSC-enriched CD34+ progenitor cells.• Inhibition of GILT in AML cells sensitized them to Ara-C treatment through ROS-mediated mitochondrial damage and apoptosis.• PI3K/Akt/NRF2 pathway inhibition is critical for the… read more here.
Keywords: mitochondrial damage; mediated mitochondrial; ros mediated; targeting ifn ... See more keywords