Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01588
Abstract: Integrins play important roles in physiological and pathophysiological processes. Among the RGD-recognizing integrin subtypes, the αvβ8 receptor is emerging as an attractive target because of its involvement in various illnesses, such as autoimmune diseases, viral… read more here.
Keywords: active cyclic; integrin highly; selective targeting; cyclic peptide ... See more keywords
Targeting β1-integrin inhibits vascular leakage in endotoxemia
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1722317115
Abstract: Significance Compromised vascular integrity is associated with capillary leakage in sepsis, but effective therapies stabilizing the vasculature are lacking. Here, we show that targeting β1-integrin in vivo with inhibitory antibodies or deletion of a single… read more here.
Keywords: leakage; endotoxemia; vascular leakage; targeting integrin ... See more keywords
Goldilocks and the Three Trials: Clinical Trials Targeting the αvβ6 Integrin in Idiopathic Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202208-1579ed
Abstract: exposure to increased or decreased ambient temperature. Sci Total Environ 2021;772:145383. 9. Willson BE, Gee NA, Willits NH, Li L, Zhang Q, Pinkerton KE, et al. Effects of the 2018 camp fire on birth outcomes… read more here.
Keywords: three trials; trials clinical; clinical trials; targeting integrin ... See more keywords
SPECT Imaging of Acute Disc Herniation by Targeting Integrin α5β1 in Rat Models
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.782967
Abstract: Objective Traditional morphological imaging of intervertebral disc herniation (IVDH) is challenging in early disease diagnosis. Aiming at the early diagnosis of IVD by non-invasive molecular imaging targeting of integrin α5β1, we performed novel imaging in… read more here.
Keywords: disc herniation; targeting integrin; spect imaging; disc ... See more keywords