Targeting integrins for cancer management using nanotherapeutic approaches: Recent advances and challenges
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in Cancer Biology"
DOI: 10.1016/j.semcancer.2019.08.030
Abstract: Integrins are the main cell surface receptors and execute multifaceted functions such as the bidirectional transmission of signals (i.e., inside-out and outside-in) and provide communication between cells and their microenvironments. Integrins are the key regulators… read more here.
Keywords: targeting integrins; based approaches; cancer management; nanotechnology ... See more keywords
Targeting integrins in drug resistant acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16149
Abstract: Acute myeloid leukemia (AML) continues to have a poor prognosis warranting new therapeutic strategies. The bone marrow (BM) microenvironment consists of niches that interact with not only normal hematopoietic stem cells (HSC), but also leukemia… read more here.
Keywords: myeloid leukemia; leukemia; targeting integrins; acute myeloid ... See more keywords
Targeting Integrins for Cancer Therapy - Disappointments and Opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.863850
Abstract: Integrins mediate adhesive interactions between cells and their environment, including neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane receptors bind extracellular ligands with their globular head domains and connect to the cytoskeleton through multi-protein… read more here.
Keywords: cancer; therapy disappointments; therapy; targeting integrins ... See more keywords