Therapeutic Targeting of Interleukin-11 Signalling Reduces Pressure Overload–Induced Cardiac Fibrosis in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-020-10054-z
Abstract: There are currently no specific treatments for cardiac fibrosis. We tested the efficacy of a neutralising anti-IL11 antibody (X203) to reduce cardiac fibrosis in two preclinical models: transverse aortic constriction (TAC) and chronic angiotensin II… read more here.
Keywords: targeting interleukin; fibrosis; cardiac fibrosis; therapeutic targeting ... See more keywords
Targeting interleukin-20 alleviates paclitaxel-induced peripheral neuropathy.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000001831
Abstract: The role of immune mediators, including pro-inflammatory cytokines in chemotherapy-induced peripheral neuropathy (CIPN), remains unclear. Here we studied the contribution of interleukin-20 (IL-20) to the development of paclitaxel-induced peripheral neuropathy. Increased serum levels of IL-20… read more here.
Keywords: targeting interleukin; paclitaxel induced; peripheral neuropathy; interleukin alleviates ... See more keywords
Targeting the interleukin-5 pathway in EGPA: evidence, uncertainties and opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/ard-2022-223044
Abstract: Only a minority of patients with eosinophilic granulomatosis with polyangiitis (EGPA) can be weaned-off glucocorticoids (GC) using conventional treatment strategies. The development of biological agents specifically inhibiting the IL-5 pathway provided the opportunity to treat… read more here.
Keywords: targeting interleukin; interleukin pathway; remission; egpa ... See more keywords
TARGETING INTERLEUKIN 17 IN THE TREATMENT OF RHEUMATOID ARTHRITIS
Sign Up to like & getrecommendations! Published in 2018 at "Farmacia"
DOI: 10.31925/farmacia.2018.3.2
Abstract: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines discovered in 1993. IL-17 drives an important pathogenic pathway in rheumatoid arthritis (RA), leading to and sustaining chronic inflammation. The recognition of this role made IL17… read more here.
Keywords: targeting interleukin; rheumatoid; interleukin treatment; rheumatoid arthritis ... See more keywords
Targeting the Interleukin-5 Pathway for Treatment of Eosinophilic Conditions Other than Asthma
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2018.00049
Abstract: Improved understanding of the contribution of eosinophils to various chronic inflammatory conditions, most notably allergic asthma, has encouraged development of monoclonal antibodies specifically targeting mediators and surface receptors involved in eosinophil expansion and activation. The… read more here.
Keywords: targeting interleukin; interleukin pathway; biology; pathway treatment ... See more keywords