Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00263
Abstract: Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range of different applications, including bioluminescence resonance energy transfer (BRET) assays. Here, we report the structure-based… read more here.
Keywords: fluorescent ligands; ccr2; allosteric binding; targeting intracellular ... See more keywords
Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2019.1570778
Abstract: ABSTRACT Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T… read more here.
Keywords: foxp3; mimic antibody; antibody; intracellular foxp3 ... See more keywords
Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC specific T-cell bispecific antibody.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020010477
Abstract: Antibody-based immunotherapy is a promising strategy for targeting chemo-resistant leukemic cells. However, classical antibody-based approaches are restricted to targeting lineage-specific cell-surface antigens. By targeting intracellular antigens, a large number of other leukemia-associated targets would become… read more here.
Keywords: targeting intracellular; specific cell; antibody; wt1 tcb ... See more keywords
Targeting of the intracellular redox balance by metal complexes towards anticancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.967337
Abstract: The development of cancers is often linked to the alteration of essential redox processes, and therefore, oxidoreductases involved in such mechanisms can be considered as attractive molecular targets for the development of new therapeutic strategies.… read more here.
Keywords: metal complexes; redox; redox balance; targeting intracellular ... See more keywords
Targeting intracellular pathways in idiopathic inflammatory myopathies: A narrative review
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1158768
Abstract: In recent decades, several pieces of evidence have drawn greater attention to the topic of innate immunity, in particular, interferon (IFN) and Interleukin 6 in the pathogenesis of idiopathic inflammatory myopathies (IIM). Both of these… read more here.
Keywords: review; idiopathic inflammatory; intracellular pathways; pathways idiopathic ... See more keywords