Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21886
Abstract: The key proteins involved in transcriptional regulation play convergent roles in cellular homeostasis, and their dysfunction mediates aberrant gene expressions that underline the hallmarks of tumorigenesis. As tumor progression is dependent on such abnormal regulation… read more here.
Keywords: targeting key; involved transcriptional; transcriptional regulation; regulation ... See more keywords
MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114357
Abstract: Pancreatic Cancer (PC) is a severe form of malignancy all over the world. Delayed diagnosis and chemoresistance are the major factors contributing to its poor prognosis and high mortality rate. The genetic and epigenetic regulations… read more here.
Keywords: directly targeting; biological pathways; pancreatic cancer; mirnas directly ... See more keywords
Targeting the key player: An incentive-based approach
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Mathematical Economics"
DOI: 10.1016/j.jmateco.2018.10.001
Abstract: We consider a network game with local complementarities. A policymaker, aiming at minimizing or maximizing aggregate effort, contracts with a single agent on the network to trade effort change against transfer. The policymaker has to… read more here.
Keywords: key player; incentive based; player incentive; player ... See more keywords
Targeting Some Key Metalloproteinases by Nano-Naringenin and Amphora coffeaeformis as a Novel Strategy for Treatment of Osteoarthritis in Rats
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020260
Abstract: Osteoarthritis (OA) represents the highest degenerative disorder. Because cartilage erosion is a common pathological alteration in OA, targeting some key metalloproteinases such as MMP-3, ADAMTS-5 besides their inhibitor TIMP-3 by natural products, could be an… read more here.
Keywords: targeting key; nano naringenin; key metalloproteinases; osteoarthritis ... See more keywords