Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201902251
Abstract: T cells help regulate immunity, which makes them an important target for RNA therapies. While nanoparticles carrying RNA have been directed to T cells in vivo using protein- and aptamer-based targeting ligands, systemic delivery to… read more here.
Keywords: without targeting; cells vivo; sirna sgrna; deliver sirna ... See more keywords
Synthesis of dendritic bisphosphonates as bone targeting ligands
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.11.028
Abstract: Abstract A dendritic bisphosphonate carrying three bisphosphonate (BP) units in close proximity was designed as a ligand to conjugate large therapeutic molecules for their bone selective delivery. The Bu3P-catalyzed conjugate addition of nitromethane to vinylidene… read more here.
Keywords: bone targeting; dendritic bisphosphonates; targeting ligands; bisphosphonates bone ... See more keywords
Accurate Physics-Based Prediction of Binding Affinities of RNA- and DNA-Targeting Ligands
Sign Up to like & getrecommendations! Published in 2025 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.4c01708
Abstract: Accurate prediction of the affinity of ligand binding to nucleic acids represents a formidable challenge for current computational approaches. This limitation has hindered the use of computational methods to develop small-molecule drugs that modulate the… read more here.
Keywords: physics; targeting ligands; prediction; rna dna ... See more keywords
Facile Fabrication of Nanoparticles with Dual Targeting Ligands for Precise Hepatocellular Carcinoma Therapy in Vitro and in Vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00327
Abstract: Efficient hepatocellular carcinoma (HCC) therapy remains a significant challenge due to the unsatisfactory targeting efficiency of nanoparticles (NPs) with either a passive targeting or a single active targeting property. Although a dual targeting mechanism-based strategy… read more here.
Keywords: hepatocellular carcinoma; therapy; hcc; vitro vivo ... See more keywords
Quantitative Control of Gene-Engineered T cell Activity Through Covalent Attachment of Targeting Ligands to a Universal Immune Receptor.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b11622
Abstract: Universal immune receptors represent a rapidly emerging form of adoptive T cell therapy with the potential to overcome safety and antigen escape challenges faced by conventional chimeric antigen receptor (CAR) T cell therapy. By decoupling… read more here.
Keywords: targeting ligands; universal immune; antigen; receptor ... See more keywords
Brain-targeted drug delivery - nanovesicles directed to specific brain cells by brain-targeting ligands
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-024-02511-7
Abstract: Neurodegenerative diseases are characterized by extensive loss of function or death of brain cells, hampering the life quality of patients. Brain-targeted drug delivery is challenging, with a low success rate this far. Therefore, the application… read more here.
Keywords: brain targeted; brain; targeting ligands; brain cells ... See more keywords
The role of formulation approaches in presenting targeting ligands on lipid nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Nanomedicine"
DOI: 10.2217/nnm-2023-0052
Abstract: Aims: The density of functional ligands on lipid nanoparticles (LNPs) greatly determined its capability of postfunctionalization and targetability for the applications of personalized nanomedicine and drug/gene delivery. This work is to investigate whether and how… read more here.
Keywords: targeting ligands; formulation; formulation methods; ligands lipid ... See more keywords
Advancing Breast Cancer Therapeutics: Targeted Gene Delivery Systems Unveiling the Potential of Estrogen Receptor-Targeting Ligands
Sign Up to like & getrecommendations! Published in 2024 at "Biomaterials Research"
DOI: 10.34133/bmr.0087
Abstract: Although curcumin has been well known as a phytochemical drug that inhibits tumor promotion by modulating multiple molecular targets, its potential was not reported as a targeting ligand in the field of drug delivery system.… read more here.
Keywords: targeting ligands; gene; breast cancer; curcumin ... See more keywords
Orthogonal Combinatorial Raman Codes Enable Rapid High-Throughput-Out Library Screening of Cell-Targeting Ligands
Sign Up to like & getrecommendations! Published in 2023 at "Research"
DOI: 10.34133/research.0136
Abstract: High-throughput assays play an important role in the fields of drug discovery, genetic analysis, and clinical diagnostics. Although super-capacity coding strategies may facilitate labeling and detecting large numbers of targets in a single assay, practically,… read more here.
Keywords: targeting ligands; screening cell; raman; high throughput ... See more keywords