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Published in 2018 at "MedChemComm"
DOI: 10.1039/c8md00301g
Abstract: A series of novel unique structural organophosphorus aminopyrimidines were developed as potential DNA-targeting membrane active inhibitors through an efficient one-pot procedure from aldehydes, phosphonate and aminopyrimidine. The biological assay revealed that some of the prepared…
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Keywords:
unique structural;
dna targeting;
dna;
targeting membrane ... See more keywords
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Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-itoc7.20
Abstract: Background Mesothelin (MSLN) is recognized as a relevant tumor-associated antigen for cancer immunotherapy, because of its overexpression on various solid tumors, including mesothelioma, pancreatic, lung, gastric and ovarian carcinoma. However, an anti-MSLN monoclonal antibody (mAb),…
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Keywords:
none;
msln;
membrane proximal;
targeting membrane ... See more keywords
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Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00012
Abstract: Cancer mortality and morbidity is projected to increase significantly over the next few decades. Current chemotherapeutic strategies have significant limitations, and there is great interest in seeking novel therapies which are capable of specifically targeting…
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Keywords:
membrane lipid;
lipid potential;
targeting membrane;
cancer cells ... See more keywords