Articles with "targeting membrane" as a keyword



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Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant Staphylococcus aureus.

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Published in 2018 at "MedChemComm"

DOI: 10.1039/c8md00301g

Abstract: A series of novel unique structural organophosphorus aminopyrimidines were developed as potential DNA-targeting membrane active inhibitors through an efficient one-pot procedure from aldehydes, phosphonate and aminopyrimidine. The biological assay revealed that some of the prepared… read more here.

Keywords: unique structural; dna targeting; dna; targeting membrane ... See more keywords
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P01.07 Targeting a membrane proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on tumor cells

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Published in 2020 at "Journal for ImmunoTherapy of Cancer"

DOI: 10.1136/jitc-2020-itoc7.20

Abstract: Background Mesothelin (MSLN) is recognized as a relevant tumor-associated antigen for cancer immunotherapy, because of its overexpression on various solid tumors, including mesothelioma, pancreatic, lung, gastric and ovarian carcinoma. However, an anti-MSLN monoclonal antibody (mAb),… read more here.

Keywords: none; msln; membrane proximal; targeting membrane ... See more keywords
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Targeting Membrane Lipid a Potential Cancer Cure?

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Published in 2017 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2017.00012

Abstract: Cancer mortality and morbidity is projected to increase significantly over the next few decades. Current chemotherapeutic strategies have significant limitations, and there is great interest in seeking novel therapies which are capable of specifically targeting… read more here.

Keywords: membrane lipid; lipid potential; targeting membrane; cancer cells ... See more keywords