Targeting un-MET needs in advanced non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Lung cancer"
DOI: 10.1016/j.lungcan.2021.12.016
Abstract: Lung cancer classification has been radically transformed in recent years as genomic profiling has identified multiple novel therapeutic targets including MET exon 14 (METex14) alterations and MET amplification. Utilizing targeted therapies in patients with molecularly-defined… read more here.
Keywords: lung; cancer targeting; resistance; lung cancer ... See more keywords
Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/nrclinonc.2018.13
Abstract: This corrects the article DOI: 10.1038/nrclinonc.2017.40 read more here.
Keywords: rationale opportunities; met gastrointestinal; targeting met; gastrointestinal tumours ... See more keywords
Generation and Characterization of a Bispecific Antibody Targeting Both PD-1 and c-MET.
Sign Up to like & getrecommendations! Published in 2018 at "Protein and peptide letters"
DOI: 10.2174/0929866524666171017143753
Abstract: BACKGROUND Bispecific antibodies, BsAbs, are molecules with the ability to bind to two different epitopes on the same or different antigens. c-MET, cellular-mesenchymal to epithelial transition factor, is deregulated in many types of human malignancies.… read more here.
Keywords: targeting met; antibody targeting; tumor cells; bispecific antibody ... See more keywords
Opportunities and challenges of targeting c-Met in the treatment of digestive tumors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.923260
Abstract: At present, a large number of studies have demonstrated that c-Met generally exerts a crucial function of promoting tumor cells proliferation and differentiation in digestive system tumors. c-Met also mediates tumor progression and drug resistance… read more here.
Keywords: treatment digestive; system tumors; targeting met; digestive system ... See more keywords
Targeting c-Met in the treatment of urologic neoplasms: Current status and challenges
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1071030
Abstract: At present, studies have found that c-Met is mainly involved in epithelial-mesenchymal transition (EMT) of tumor tissues in urologic neoplasms. Hepatocyte growth factor (HGF) combined with c-Met promotes the mitosis of tumor cells, and then… read more here.
Keywords: targeting met; urologic neoplasms; treatment urologic; neoplasms current ... See more keywords
Quinoline-Based Molecules Targeting c-Met, EGF, and VEGF Receptors and the Proteins Involved in Related Carcinogenic Pathways
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25184279
Abstract: The quinoline ring system has long been known as a versatile nucleus in the design and synthesis of biologically active compounds. Currently, more than one hundred quinoline compounds have been approved in therapy as antimicrobial,… read more here.
Keywords: met egf; targeting met; based molecules; molecules targeting ... See more keywords