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Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.01.019
Abstract: The unique metabolic demand of cancer cells suggests a new therapeutic strategy targeting the metabolism in cancers. V9302 is a recently reported inhibitor of ASCT2 amino acid transporter which shows promising antitumor activity by blocking…
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Keywords:
metabolism;
delivery;
targeting metabolism;
poeg 2dg ... See more keywords
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Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2016.08.049
Abstract: Cellular senescence has gained much attention as a contributor to aging and susceptibility to disease. Senescent cells undergo a stable cell cycle arrest and produce pro-inflammatory cytokines. However, an additional feature of the senescence phenotype…
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Keywords:
metabolism cellular;
metabolic changes;
senescence;
targeting metabolism ... See more keywords
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Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/s41573-019-0032-5
Abstract: Metabolic programming is emerging as a critical mechanism to alter immune cell activation, differentiation and function. Targeting metabolism does not completely suppress or activate the immune system but selectively regulates immune responses. The different metabolic…
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Keywords:
metabolism;
immune responses;
targeting metabolism;
metabolism regulate ... See more keywords
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Published in 2022 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v10.i10.2990
Abstract: Most hematological cancer-related relapses and deaths are caused by metastasis; thus, the importance of this process as a target of therapy should be considered. Hematological cancer is a type of cancer in which metabolism plays…
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Keywords:
targeting metabolism;
metabolism potential;
therapy;
hematological cancer ... See more keywords
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Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.943906
Abstract: Cancer cells reprogram their metabolism to meet their growing demand for bioenergy and biosynthesis. The metabolic profile of cancer cells usually includes dysregulation of main nutritional metabolic pathways and the production of metabolites, which leads…
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Keywords:
metabolism;
targeting metabolism;
cancer;
tumor microenvironment ... See more keywords
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Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.845923
Abstract: Although immunotherapy has achieved good results in various cancer types, a large proportion of patients are limited from the benefits. Hypoxia and metabolic reprogramming are the common and critical factors that impact immunotherapy response. Here,…
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Keywords:
metabolism;
microenvironment;
targeting metabolism;
immunotherapy ... See more keywords