Targeting Microglia to Treat Degenerative Eye Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.843558
Abstract: Microglia have been implicated in many degenerative eye disorders, including retinitis pigmentosa, age-related macular degeneration, glaucoma, diabetic retinopathy, uveitis, and retinal detachment. While the exact roles of microglia in these conditions are still being discovered,… read more here.
Keywords: targeting microglia; eye; eye diseases; microglia treat ... See more keywords
Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00286
Abstract: Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system (CNS). The early stage is characterized by relapses and the later stage, by progressive disability. Results from experimental and clinical investigations… read more here.
Keywords: macrophages potential; treatment; targeting microglia; multiple sclerosis ... See more keywords
Targeting Microglia in Alzheimer’s Disease: From Molecular Mechanisms to Potential Therapeutic Targets for Small Molecules
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27134124
Abstract: Alzheimer’s disease (AD) is a common, progressive, and devastating neurodegenerative disorder that mainly affects the elderly. Microglial dysregulation, amyloid-beta (Aβ) plaques, and intracellular neurofibrillary tangles play crucial roles in the pathogenesis of AD. In the… read more here.
Keywords: microglia alzheimer; targeting microglia; alzheimer disease; brain ... See more keywords
A new genetic strategy for targeting microglia in development and disease
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.54590
Abstract: As the resident macrophages of the brain and spinal cord, microglia are crucial for the phagocytosis of infectious agents, apoptotic cells and synapses. During brain injury or infection, bone-marrow derived macrophages invade neural tissue, making… read more here.
Keywords: microglia; development; development disease; targeting microglia ... See more keywords