New Biocompatible β‐Phosphorylated Linear Nitrones Targeting Mitochondria: Protective Effect in Apoptotic Cells
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200749
Abstract: The mitochondrion, an essential organelle involved in cellular respiration, energy production, and cell death, is the main cellular source of reactive oxygen species (ROS), including superoxide. Mitochondrial diseases resulting from uncontrolled/excess ROS generation are an… read more here.
Keywords: new biocompatible; biocompatible phosphorylated; targeting mitochondria; phosphorylated linear ... See more keywords
Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives
Sign Up to like & getrecommendations! Published in 2019 at "CNS Drugs"
DOI: 10.1007/s40263-019-00658-8
Abstract: A decline in mitochondrial function plays a key role in the aging process and increases the incidence of age-related disorders, including Alzheimer disease (AD). Mitochondria—the power station of the organism—can affect several different cellular activities,… read more here.
Keywords: mitochondria alzheimer; alzheimer disease; disease; disease rationale ... See more keywords
Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis Signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.05.014
Abstract: Mitochondrial outer membrane permeabilization (MOMP) is a core event in apoptosis signaling. However, the underlying mechanism of BAX and BAK pore formation remains incompletely understood. We demonstrate that mitochondria are globally and dynamically targeted by… read more here.
Keywords: bax; apoptosis; momp; targeting mitochondria ... See more keywords
A New Infrared Probe Targeting Mitochondria via Regulation of Molecular Hydrophobicity.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00845
Abstract: Herein, we developed a near-infrared (NIR) fluorescent probe for mitochondrial staining based on the NIR fluorochrome, silicon-rhodamine. The hydrophobicity of the fluorescent core was systematically modified by conjugation with 10 different commercial amines. The resulting… read more here.
Keywords: infrared probe; new infrared; probe; targeting mitochondria ... See more keywords
Targeting the Mitochondria with Pseudo-Stealthy Nanotaxanes to Impair Mitochondrial Biogenesis for Effective Cancer Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c08008
Abstract: The clinical success of anticancer therapy is usually limited by drug resistance and the metastatic dissemination of cancer cells. Mitochondria are essential generators of cellular energy and play a crucial role in sustaining cell survival… read more here.
Keywords: targeting mitochondria; pseudo stealthy; drug; mitochondria pseudo ... See more keywords
Enzymatic Cleavage of Branched Peptides for Targeting Mitochondria.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b11582
Abstract: Most of the reported mitochondria-targeting molecules are lipophilic and cationic, and thus they may become cytotoxic with accumulation. Here we show enzymatic cleavage of branched peptides that carry negative charges for targeting mitochondria. Conjugating a… read more here.
Keywords: branched peptides; peptides targeting; cleavage branched; targeting mitochondria ... See more keywords
Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-018-0074-0
Abstract: A large body of evidence indicates that mitochondrial dysfunction has a major role in the pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary efforts have been focused on the development of agents… read more here.
Keywords: cardiovascular disease; pathogenesis; targeting mitochondria; cardiovascular disorders ... See more keywords
Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer †
Sign Up to like & getrecommendations! Published in 2022 at "Photochemistry and Photobiology"
DOI: 10.1111/php.13723
Abstract: Ovarian cancer is the most lethal gynecologic malignancy with a stubborn mortality rate of ~65%. The persistent failure of multiline chemotherapy, and significant tumor heterogeneity, has made it challenging to improve outcomes. A target of… read more here.
Keywords: ovarian cancer; targeting mitochondria; photochemical targeting; chemoresistance ... See more keywords
Targeting Mitochondria in Age-Related Vascular Changes: A New Arrow to the Bow of Antioxidant Treatment?
Sign Up to like & getrecommendations! Published in 2018 at "Hypertension"
DOI: 10.1161/hypertensionaha.118.10869
Abstract: See related article, pp 1056–1063 Aging is a powerful determinant of vascular changes, being associated with elastin degradation and accumulation of collagen fibers within the vascular wall, ultimately leading to increased arterial stiffness. The ability… read more here.
Keywords: stiffness; age related; mitochondria age; vascular changes ... See more keywords
The Potential of Melatonin to treat Atherosclerosis by Targeting Mitochondria.
Sign Up to like & getrecommendations! Published in 2023 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026623666230116102054
Abstract: As a circadian rhythm hormone, melatonin is widely present in the body and has rich physiological functions. Compared to its prominent circadian role, melatonin has been extensively studied in many fields as an ancient antioxidant.… read more here.
Keywords: treat atherosclerosis; potential melatonin; targeting mitochondria; atherosclerosis ... See more keywords
Phytochemical Targeting of Mitochondria for Breast Cancer Chemoprevention, Therapy, and Sensitization
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214152
Abstract: Breast cancer is a common and deadly disease that causes tremendous physical, emotional, and financial burden on patients and society. Early-stage breast cancer and less aggressive subtypes have promising prognosis for patients, but in aggressive… read more here.
Keywords: breast cancer; phytochemical targeting; targeting mitochondria; cancer ... See more keywords