Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.03.003
Abstract: The potassium channel Kv1.3 is highly expressed in the mitochondria of various cancerous cells. Here we show that direct inhibition of Kv1.3 using two mitochondria-targeted inhibitors alters mitochondrial function and leads to reactive oxygen species… read more here.
Keywords: cells vivo; tumor cells; pharmacological targeting; targeting mitochondrial ... See more keywords
Primers targeting mitochondrial genes of avian haemosporidians: PCR detection and differential DNA amplification of parasites belonging to different genera.
Sign Up to like & getrecommendations! Published in 2018 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2018.02.003
Abstract: Haemosporida is a diverse group of vector-borne parasitic protozoa, ubiquitous in terrestrial vertebrates worldwide. The renewed interest in their diversity has been driven by the extensive use of molecular methods targeting mitochondrial genes. Unfortunately, most… read more here.
Keywords: detection; mitochondrial genes; dna; different genera ... See more keywords
Targeting the mitochondrial chaperone TRAP1: strategies and therapeutic perspectives.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2021.04.003
Abstract: TRAP1, the mitochondrial isoform of heat shock protein (Hsp)90 chaperones, is a key regulator of metabolism and organelle homeostasis in diverse pathological states. While selective TRAP1 targeting is an attractive goal, classical active-site-directed strategies have… read more here.
Keywords: mitochondrial chaperone; strategies therapeutic; trap1 strategies; chaperone trap1 ... See more keywords
Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci120844
Abstract: Mammalian cells use a complex network of redox-dependent processes necessary to maintain cellular integrity during oxidative metabolism, as well as to protect against and/or adapt to stress. The disruption of these redox-dependent processes, including those… read more here.
Keywords: evidence targeting; metabolism; emerging evidence; cancer ... See more keywords
Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "Aging and disease"
DOI: 10.14336/ad.2023.0203
Abstract: Aging is a natural and complex biological process that is associated with widespread functional declines in numerous physiological processes, terminally affecting multiple organs and tissues. Fibrosis and neurodegenerative diseases (NDs) often occur with aging, imposing… read more here.
Keywords: age related; disease; mitochondrial sirtuins; targeting mitochondrial ... See more keywords
Targeting mitochondrial quality control of T cells: Regulating the immune response in HCC
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.993437
Abstract: Most of the primary hepatocellular carcinoma (HCC) develops from Viral Hepatitis including Hepatitis B virus, Hepatitis C Virus, and Nonalcoholic Steatohepatitis. Herein, T cells play crucial roles combined with chronic inflammation and chronic viral infection.… read more here.
Keywords: quality control; hcc; mitochondrial quality; targeting mitochondrial ... See more keywords
Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1142001
Abstract: The patients with kidney diseases are increasing rapidly all over the world. With the rich abundance of mitochondria, kidney is an organ with a high consumption of energy. Hence, renal failure is highly correlated with… read more here.
Keywords: mitochondrial dysfunction; natural products; kidney disease; targeting mitochondrial ... See more keywords
Targeting Mitochondrial Metabolism to Reverse Radioresistance: An Alternative to Glucose Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11112202
Abstract: Radiotherapy failure and poor tumor prognosis are primarily attributed to radioresistance. Improving the curative effect of radiotherapy and delaying cancer progression have become difficult problems for clinicians. Glucose metabolism has long been regarded as the… read more here.
Keywords: metabolism; mitochondrial metabolism; metabolism reverse; glucose metabolism ... See more keywords
Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection
Sign Up to like & getrecommendations! Published in 2019 at "Brain Sciences"
DOI: 10.3390/brainsci9090238
Abstract: The mitochondrial pyruvate carriers mediate pyruvate import into the mitochondria, which is key to the sustenance of the tricarboxylic cycle and oxidative phosphorylation. However, inhibition of mitochondria pyruvate carrier-mediated pyruvate transport was recently shown to… read more here.
Keywords: pyruvate; carrier neuroprotection; pyruvate carrier; targeting mitochondrial ... See more keywords
Targeting the Mitochondrial Protein VDAC1 as a Potential Therapeutic Strategy in ALS
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179946
Abstract: Impaired mitochondrial function has been proposed as a causative factor in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), caused by motor neuron degeneration. Mutations in superoxide dismutase (SOD1) cause ALS and SOD1 mutants were shown… read more here.
Keywords: vdac1; vdac1 potential; mitochondrial protein; targeting mitochondrial ... See more keywords
Targeting Mitochondrial Dynamics Proteins for the Development of Therapies for Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314741
Abstract: Cardiovascular diseases are one of the leading causes of death worldwide. The identification of new pathogenetic targets contributes to more efficient development of new types of drugs for the treatment of cardiovascular diseases. This review… read more here.
Keywords: dynamics proteins; proteins development; cardiovascular diseases; mitochondrial dynamics ... See more keywords