Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02030
Abstract: Chromosomal instability (CIN) is a hallmark of cancer that results from errors in chromosome segregation during mitosis. Targeting of CIN-associated vulnerabilities is an emerging therapeutic strategy in drug development. KIF18A, a mitotic kinesin, has been… read more here.
Keywords: mitotic kinesin; kif18a; kinesin kif18a; chemical ... See more keywords
Targeting mitotic pathways for endocrine-related cancer therapeutics.
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine-related cancer"
DOI: 10.1530/erc-17-0080
Abstract: A colossal amount of basic research over the past few decades has provided unprecedented insights into the highly complex process of cell division. There is an ever-expanding catalog of proteins that orchestrate, participate and coordinate… read more here.
Keywords: pathways endocrine; related cancer; targeting mitotic; mitotic pathways ... See more keywords