Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2021.2023696
Abstract: Abstract As mitochondria are potential therapeutic targeting sites for the treatment of human diseases, delivering cytotoxic drugs, antioxidants, and imaging molecules to mitochondria can provide new therapeutic opportunities. In an attempt to develop a new… read more here.
Keywords: molecular transporter; mitochondria targeting; ionic complex; targeting molecular ... See more keywords
THERAPEUTIC TARGETING OF MOLECULAR PATHWAYS IN COLORECTAL CANCER.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental oncology"
DOI: 10.32471/exp-oncology.2312-8852.vol-44-no-1.17455
Abstract: Mutations in tumor suppressor genes, cell signaling, and genes associated with DNA repair lead to onset of colorectal cancer (CRC). Even though most CRC patients get clinical benefits from conventional treatments such as chemotherapy and… read more here.
Keywords: therapeutic targeting; colorectal cancer; molecular pathways; pathways colorectal ... See more keywords
Targeting Molecular Inflammatory Pathways in Granuloma as Host-Directed Therapies for Tuberculosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.733853
Abstract: Globally, more than 10 million people developed active tuberculosis (TB), with 1.4 million deaths in 2020. In addition, the emergence of drug-resistant strains in many regions of the world threatens national TB control programs. This… read more here.
Keywords: targeting molecular; host directed; directed therapies; inflammatory ... See more keywords
Targeting Molecular Mechanisms Underlying Treatment Efficacy and Resistance in Osteosarcoma: A Review of Current and Future Strategies
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DOI: 10.3390/ijms21186885
Abstract: Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure. Introduction of combination chemotherapy in the 1970s, however, dramatically increased overall… read more here.
Keywords: targeting molecular; treatment; underlying treatment; resistance ... See more keywords
Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.69618
Abstract: Aristolochic acid (AA), mainly derived from herbal Aristolochia and Asarum plants, was listed as a human carcinogen class I in 2002. Aristolochic acid nephropathy (AAN) is a rapidly progressive tubulointerstitial nephritis and urothelial cancer caused… read more here.
Keywords: aristolochic acid; targeting molecular; molecular mechanisms; induced nephrotoxicity ... See more keywords