Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113824
Abstract: Hepatocellular carcinoma (HCC) is a major contributor to global cancer incidence and mortality. Many pathways are involved in the development of HCC and various proteins including mTOR and HDACs have been identified as potential drug… read more here.
Keywords: hepatocellular carcinoma; treatment; hdacs; mtor hdacs ... See more keywords
Flavonoids Targeting the mTOR Signaling Cascades in Cancer: A Potential Crosstalk in Anti-Breast Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4831833
Abstract: Cancer is one of the leading causes of death worldwide. Breast cancer is the second leading cause of death in women, with triple-negative breast cancer being the most lethal and aggressive form. Conventional therapies, such… read more here.
Keywords: targeting mtor; breast cancer; cancer; mtor signaling ... See more keywords
Challenges and Emerging Opportunities for Targeting mTOR in Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-0602
Abstract: The mechanistic target of rapamycin (mTOR) plays a key role in normal and malignant cell growth. However, pharmacologic targeting of mTOR in cancer has shown little clinical benefit, in spite of aberrant hyperactivation of mTOR… read more here.
Keywords: targeting mtor; mtor cancer; challenges emerging; emerging opportunities ... See more keywords
Targeting mTOR in Head and Neck Cancer—Response
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DOI: 10.1158/1078-0432.ccr-19-2002
Abstract: We thank Masterson and colleagues for the kind and insightful comments, and for highlighting our team's efforts aimed at translating the emerging information of the head and neck cancer (HNSCC) oncogenome into new precision therapeutic… read more here.
Keywords: targeting mtor; neck cancer; cancer; head neck ... See more keywords
Targeting mTOR in the context of diet and whole-body metabolism.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac041
Abstract: The mechanistic target of rapamycin (mTOR) signaling pathway is the central regulator of cell growth and proliferation by integrating growth factor and nutrient availability. Under healthy physiological conditions, this process is tightly coordinated and essential… read more here.
Keywords: targeting mtor; metabolism; mtor inhibitors; whole body ... See more keywords
MiR-99a inhibits cell proliferation of nasopharyngeal carcinoma by targeting mTOR and serves as a prognostic factor.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201903_17246
Abstract: OBJECTIVE Nasopharyngeal carcinoma is the most common head and neck tumor in Southern China and Southeast Asia, presenting high rates of local invasion and early distant metastasis. Abnormally expressed miR-99a has been discovered in many… read more here.
Keywords: 99a inhibits; targeting mtor; mir 99a; mtor ... See more keywords
Targeting mTOR as a Cancer Therapy: Recent Advances in Natural Bioactive Compounds and Immunotherapy
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DOI: 10.3390/cancers14225520
Abstract: The mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine-protein kinase, which regulates many biological processes related to metabolism, cancer, immune function, and aging. It is an essential protein kinase that belongs to the… read more here.
Keywords: targeting mtor; mtor signaling; cancer therapy; mtor ... See more keywords