Targeting multiple conformations of SARS-CoV2 Papain-Like Protease for drug repositioning: An in-silico study
Sign Up to like & getrecommendations! Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2021.104295
Abstract: Papain-Like Protease (PLpro) is a key protein for SARS-CoV-2 viral replication which is the cause of the emerging COVID-19 pandemic. Targeting PLpro can suppress viral replication and provide treatment options for COVID-19. Due to the… read more here.
Keywords: drug repositioning; targeting multiple; multiple conformations; like protease ... See more keywords
Tailoring a lead-like compound targeting multiple G-quadruplex structures.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.058
Abstract: A focused library of analogs of a lead-like G-quadruplex (G4) targeting compound (4), sharing a furobenzoxazine naphthoquinone core and differing for the pendant groups on the N-atom of the oxazine ring, has been here analyzed… read more here.
Keywords: tailoring lead; targeting multiple; like compound; lead like ... See more keywords
A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse
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DOI: 10.1038/s41598-017-00654-2
Abstract: The most powerful way to probe protein function is to characterize the consequence of its deletion. Compared to conventional gene knockout (KO), conditional knockout (cKO) provides an advanced gene targeting strategy with which gene deletion… read more here.
Keywords: targeting multiple; multiple genes; strategy; conditional knockout ... See more keywords
Single Virus Targeting Multiple Organs: What We Know and Where We Are Heading?
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2020.00370
Abstract: COVID-19 caused by SARS-CoV-2 has already infected more than 6. 3 million people worldwide as of 1st June 2020 and caused a global medical emergency. Healthcare professionals have been struggling to devise appropriate therapeutic strategies… read more here.
Keywords: organs know; targeting multiple; single virus; virus targeting ... See more keywords
Balanced Cellular and Humoral Immune Responses Targeting Multiple Antigens in Adults Receiving a Quadrivalent Inactivated Influenza Vaccine
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DOI: 10.3390/vaccines9050426
Abstract: The role of T cell immunity has been acknowledged in recent vaccine development and evaluation. We tested the humoral and cellular immune responses to Flucelvax®, a quadrivalent inactivated seasonal influenza vaccine containing two influenza A… read more here.
Keywords: influenza vaccine; targeting multiple; quadrivalent inactivated; immune responses ... See more keywords