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   Articles with "targeting multiple" as a keyword



Targeting multiple conformations of SARS-CoV2 Papain-Like Protease for drug repositioning: An in-silico study

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recommendations! Published in 2021 at "Computers in Biology and Medicine"

DOI: 10.1016/j.compbiomed.2021.104295

Abstract: Papain-Like Protease (PLpro) is a key protein for SARS-CoV-2 viral replication which is the cause of the emerging COVID-19 pandemic. Targeting PLpro can suppress viral replication and provide treatment options for COVID-19. Due to the… read more here.

Keywords: drug repositioning; targeting multiple; multiple conformations; like protease ... See more keywords
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Tailoring a lead-like compound targeting multiple G-quadruplex structures.

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recommendations! Published in 2019 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2018.11.058

Abstract: A focused library of analogs of a lead-like G-quadruplex (G4) targeting compound (4), sharing a furobenzoxazine naphthoquinone core and differing for the pendant groups on the N-atom of the oxazine ring, has been here analyzed… read more here.

Keywords: tailoring lead; targeting multiple; like compound; lead like ... See more keywords

A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-00654-2

Abstract: The most powerful way to probe protein function is to characterize the consequence of its deletion. Compared to conventional gene knockout (KO), conditional knockout (cKO) provides an advanced gene targeting strategy with which gene deletion… read more here.

Keywords: targeting multiple; multiple genes; strategy; conditional knockout ... See more keywords

Natural Compound Dioscin Targeting Multiple Cancer Pathways through its High Affinity Binding to B Cell Lymphoma-2.

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recommendations! Published in 2024 at "Current computer-aided drug design"

DOI: 10.2174/0115734099279130231211053542

Abstract: OBJECTIVE The study aimed to explore the crucial genes involved in cancer-related biological processes, including EMT, autophagy, apoptosis, anoikis, and metastasis. It also sought to identify common genes among the pathways linked to these biological… read more here.

Keywords: cancer; targeting multiple; dioscin; cell lymphoma ... See more keywords
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Single Virus Targeting Multiple Organs: What We Know and Where We Are Heading?

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recommendations! Published in 2020 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2020.00370

Abstract: COVID-19 caused by SARS-CoV-2 has already infected more than 6. 3 million people worldwide as of 1st June 2020 and caused a global medical emergency. Healthcare professionals have been struggling to devise appropriate therapeutic strategies… read more here.

Keywords: organs know; targeting multiple; single virus; virus targeting ... See more keywords

Targeting the Multiple Complex Processes of Hypoxia-Ischemia to Achieve Neuroprotection

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms25105449

Abstract: Hypoxic-ischemic encephalopathy (HIE) is a major cause of newborn brain damage stemming from a lack of oxygenated blood flow in the neonatal period. Twenty-five to fifty percent of asphyxiated infants who develop HIE die in… read more here.

Keywords: targeting multiple; ischemia achieve; multiple complex; hypoxia ischemia ... See more keywords

Balanced Cellular and Humoral Immune Responses Targeting Multiple Antigens in Adults Receiving a Quadrivalent Inactivated Influenza Vaccine

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recommendations! Published in 2021 at "Vaccines"

DOI: 10.3390/vaccines9050426

Abstract: The role of T cell immunity has been acknowledged in recent vaccine development and evaluation. We tested the humoral and cellular immune responses to Flucelvax®, a quadrivalent inactivated seasonal influenza vaccine containing two influenza A… read more here.

Keywords: influenza vaccine; targeting multiple; quadrivalent inactivated; immune responses ... See more keywords