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   Articles with "targeting mutant" as a keyword



Abstract 6717: Targeting mutant KRAS proteins with novel TCR-mimic fully human antibodies

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-6717

Abstract: Mutated KRAS proteins are ideal cancer targets, as they are expressed frequently and specifically in certain solid tumors. A large proportion of human colorectal cancer and pancreatic ductal adenocarcinoma express the tumor driver KRAS gene… read more here.

Keywords: cancer; tcr mimic; kras proteins; targeting mutant ... See more keywords

Precision Targeting of Mutant PI3Kα.

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recommendations! Published in 2024 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-23-1392

Abstract: PIK3CA, which encodes the p110α catalytic subunit of PI 3-kinase alpha (PI3Kα), is one of the most frequently genetically activated kinases in solid tumors. In two back-to-back papers, Varkaris and colleagues report on the development… read more here.

Keywords: mutant pi3k; precision targeting; targeting mutant; pi3k ... See more keywords

Targeting Mutant p53 for Cancer Treatment: Moving Closer to Clinical Use?

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14184499

Abstract: Simple Summary Cancer is largely caused by genetic alterations such as mutations in a group of genes known as cancer driver genes. Many of the key advances in cancer treatment in recent years have involved… read more here.

Keywords: mutant p53; targeting mutant; p53; cancer treatment ... See more keywords

Identification and Targeting of Mutant Neoantigens in Multiple Myeloma Treatment

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recommendations! Published in 2023 at "Current Oncology"

DOI: 10.3390/curroncol30050348

Abstract: Multiple myeloma (MM) is malignant disease characterized by the clonal proliferation of plasma cells in the bone marrow, leading to anemia, immunosuppression, and other symptoms, that is generally hard to treat. In MM, the immune… read more here.

Keywords: targeting mutant; identification targeting; neoantigens multiple; mutant neoantigens ... See more keywords