Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27875-4
Abstract: Muscle cell death in polymyositis is induced by CD8 + cytotoxic T lymphocytes. We hypothesized that the injured muscle fibers release pro-inflammatory molecules, which would further accelerate CD8 + cytotoxic T lymphocytes-induced muscle injury, and… read more here.
Keywords: necroptosis; muscle; muscle fibers; cell death ... See more keywords
Targeting necroptosis for the treatment of myositis
Sign Up to like & getrecommendations! Published in 2022 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-022-00775-7
Abstract: New evidence implicates necroptosis in muscle fibre damage in idiopathic inflammatory myopathies, but is it too soon to suggest that interfering with this cell-death pathway could offer a novel therapeutic strategy? read more here.
Keywords: rheumatology; treatment myositis; targeting necroptosis; necroptosis treatment ... See more keywords
Repurposing anticancer drugs for targeting necroptosis
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2018.1442626
Abstract: ABSTRACT Necroptosis represents a form of programmed cell death that can be engaged by various upstream signals, for example by ligation of death receptors, by viral sensors or by pattern recognition receptors. It depends on… read more here.
Keywords: targeting necroptosis; drugs targeting; necroptosis; drug ... See more keywords