LncRNA MEG3 reverses CCl4-induced liver fibrosis by targeting NLRC5.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174462
Abstract: Liver fibrosis is a persistent pathological repair of chronic liver injury, which is characterized by excessive deposition of collagen-dominated extracellular matrix (ECM). It is well known that hepatic fibrosis can be reversed in the absence… read more here.
Keywords: targeting nlrc5; meg3; fibrosis; lncrna meg3 ... See more keywords
Targeting NLRC5 in cardiomyocytes protects postinfarction cardiac injury by enhancing autophagy flux through the CAVIN1/CAV1 axis
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-07755-z
Abstract: NOD-like receptor (NLR) family proteins are implicated in various cardiovascular diseases. However, the precise role of NLRC5, the largest member of this family, in myocardial infarction (MI) remains poorly understood. This study reveals that NLRC5… read more here.
Keywords: autophagy flux; cav1; nlrc5 cardiomyocytes; targeting nlrc5 ... See more keywords