Targeting NLRP3 inflammasome as a promising approach for treatment of diabetic nephropathy: Preclinical evidences with therapeutic approaches.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173503
Abstract: Diabetes mellitus is an increasingly prevalent disease around the globe. The epidemic of diabetes mellitus and its complications pretenses the foremost health threat globally. Diabetic nephropathy is the notable complication in diabetes, leading to end-stage… read more here.
Keywords: kidney diseases; inflammasome promising; targeting nlrp3; diabetic nephropathy ... See more keywords
Targeting the NLRP3 inflammasome in inflammatory diseases
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Drug Discovery"
DOI: 10.1038/nrd.2018.149
Abstract: This corrects the article DOI: 10.1038/nrd.2018.97 read more here.
Keywords: targeting nlrp3; nlrp3 inflammasome; inflammatory diseases; inflammasome inflammatory ... See more keywords
Investigation of the mechanism by which miR-223-3p inhibits reflux esophagitis through targeting the NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2025 at "BMC Gastroenterology"
DOI: 10.1186/s12876-025-03836-9
Abstract: Reflux esophagitis is a common gastrointestinal disorder characterized by significant inflammatory responses. The NLRP3 inflammasome plays a crucial role in inflammation, and miR- 223 - 3p has been found to inhibit its expression by targeting NLRP3… read more here.
Keywords: esophagitis targeting; mir 223; nlrp3 inflammasome; reflux esophagitis ... See more keywords
Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-024-03182-9
Abstract: Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer’s disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-associated neuroinflammation is the… read more here.
Keywords: neuroinflammation improve; neuroinflammation; function; pathology ... See more keywords
Targeting the NLRP3 Inflammasome in Diabetic Nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Current medicinal chemistry"
DOI: 10.2174/0929867328666210705153109
Abstract: Diabetic nephropathy (DN) is one of the most common complications of diabetes and the main cause of end-stage renal disease (ESRD). The inflammatory response plays a key role in the pathological process of DN. As… read more here.
Keywords: chemistry; targeting nlrp3; diabetic nephropathy; inflammasome diabetic ... See more keywords
Targeting NLRP3-Mediated Neuroinflammation in Alzheimer’s Disease Treatment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23168979
Abstract: Alzheimer’s disease (AD) is the most common cause of dementia in the general population and, to date, constitutes a major therapeutic challenge. In the pathogenesis of AD, aggregates of amyloid β (Aβ) and neurofibrillary tangles… read more here.
Keywords: mediated neuroinflammation; alzheimer disease; pathology; targeting nlrp3 ... See more keywords