[Therapeutic targeting of Notch signaling in cancer].
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin du cancer"
DOI: 10.1016/j.bulcan.2017.07.007
Abstract: The Notch pathway plays an essential role during embryonal development and tissue in adults. Notch signaling occurs through transmembrane receptors which undergo several proteolytic cleavages that lead to the release of the Notch intracytoplasmic domain… read more here.
Keywords: signaling cancer; targeting notch; notch; notch signaling ... See more keywords
Targeting Notch-Driven Cytokine Secretion: Novel Therapies for Triple Negative Breast Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2022.0578
Abstract: Compared with other breast cancer subtypes, triple negative breast cancer (TNBC) is an aggressive malignancy with a high recurrence rate and reduced overall survival. Immune checkpoint inhibition (ICI) has shown modest results in this subgroup,… read more here.
Keywords: negative breast; breast; triple negative; breast cancer ... See more keywords
Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01958
Abstract: Understanding and targeting Notch signaling effectively has long been valued in the field of cancer and other immune disorders. Here, we discuss key discoveries at the intersection of Notch signaling, cancer and immunology. While there… read more here.
Keywords: targeting notch; notch ligand; immune responses; ligand ... See more keywords
Targeting Notch to Maximize Chemotherapeutic Benefits: Rationale, Advanced Strategies, and Future Perspectives
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13205106
Abstract: Simple Summary The Notch signaling pathway regulates cell proliferation, apoptosis, stem cell self-renewal, and differentiation in a context-dependent fashion both during embryonic development and in adult tissue homeostasis. Consistent with its pleiotropic physiological role, unproper… read more here.
Keywords: targeting notch; notch; stem cell; chemotherapeutic drugs ... See more keywords
S-Adenosylmethionine Inhibits Colorectal Cancer Cell Migration through Mirna-Mediated Targeting of Notch Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147673
Abstract: Metastasis is a leading cause of mortality and poor prognosis in colorectal cancer (CRC). Thus, the identification of new compounds targeting cell migration represents a major clinical challenge. Recent findings evidenced a central role for… read more here.
Keywords: migration; cell migration; notch; targeting notch ... See more keywords