Targeting a novel apoptotic pathway in human disease
Sign Up to like & getrecommendations! Published in 2023 at "BioEssays"
DOI: 10.1002/bies.202200231
Abstract: Apoptotic pathways have always been regarded as a key‐player in preserving tissue and organ homeostasis. Excessive activation or resistance to activation of cell death signaling may indeed be responsible for several mechanisms of disease, including… read more here.
Keywords: targeting novel; apoptotic pathway; disease; death ... See more keywords
Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01334
Abstract: RAS proteins are central in the proliferation of many types of cancer, but a general approach toward the identification of pan-mutant RAS inhibitors has remained unresolved. In this work, we describe the application of a… read more here.
Keywords: novel kras; kras binding; site application; binding site ... See more keywords
Brg-1 targeting of novel miR550a-5p/RNF43/Wnt signaling axis regulates colorectal cancer metastasis
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.317
Abstract: This corrects the article DOI: 10.1038/onc.2015.124 read more here.
Keywords: rnf43 wnt; wnt signaling; brg targeting; mir550a rnf43 ... See more keywords
Molecular Targeting and Novel Therapeutic approaches against Fungal Infections
Sign Up to like & getrecommendations! Published in 2023 at "Current Molecular Medicine"
DOI: 10.2174/1566524023666230302123310
Abstract: Fungal infections have become a worldwide problem due to their involvement in numerous diseases. The risk factors for fungal infections are multiple surgeries, transplant therapies, frequent administration of antibiotics, cancer treatments, and prosthetic devices. The… read more here.
Keywords: targeting novel; novel therapeutic; antifungal drugs; resistance ... See more keywords
Targeting B7-H3—A Novel Strategy for the Design of Anticancer Agents for Extracranial Pediatric Solid Tumors Treatment
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28083356
Abstract: Recent scientific data recognize the B7-H3 checkpoint molecule as a potential target for immunotherapy of pediatric solid tumors (PSTs). B7-H3 is highly expressed in extracranial PSTs such as neuroblastoma, rhabdomyosarcoma, nephroblastoma, osteosarcoma, and Ewing sarcoma,… read more here.
Keywords: targeting novel; anti tumor; pediatric solid; novel strategy ... See more keywords