Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics.
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DOI: 10.1021/acsmedchemlett.2c00094
Abstract: On the basis of the knowledge that the proline-rich hot spot PPPRPP region of P(151)PSNPPPRPP(160), an oligopeptide derived from the cytosolic portion of p22phox (p22), binds to the single functional bis-SH3 domain of the regulatory… read more here.
Keywords: phox; triproline; p47; targeting nox2 ... See more keywords