Therapeutic effects of moxibustion simultaneously targeting Nrf2 and NF-κB in diabetic peripheral neuropathy
Sign Up to like & getrecommendations! Published in 2019 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-019-03052-8
Abstract: Moxibustion is the main alternative medicine treatment that has been beneficial to diabetic peripheral neuropathy (DPN), a common complication secondary to diabetic microvascular injury. However, the underlying protective mechanism of moxibustion against neuroinflammation remains unclear.… read more here.
Keywords: moxibustion; peripheral neuropathy; simultaneously targeting; targeting nrf2 ... See more keywords
Phytochemical compounds targeting on Nrf2 for chemoprevention in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173588
Abstract: Colorectal cancer (CRC) has become one of the major factors of tumor-related morbidity and mortality in the world because of its poor prognosis and consequences of metastatic spread. Currently, chemoprevention has been considered as a… read more here.
Keywords: colorectal cancer; chemoprevention; targeting nrf2; cancer ... See more keywords
Targeting Nrf2 for the treatment of Duchenne Muscular Dystrophy
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101803
Abstract: Imbalances in redox homeostasis can result in oxidative stress, which is implicated in various pathological conditions including the fatal neuromuscular disease Duchenne Muscular Dystrophy (DMD). DMD is a complicated disease, with many druggable targets at… read more here.
Keywords: treatment; targeting nrf2; muscular dystrophy; duchenne muscular ... See more keywords
Targeting NRF2 to promote epithelial repair
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220228
Abstract: The transcription factor NRF2 is well known as a master regulator of the cellular stress response. As such, activation of NRF2 has gained widespread attention for its potential to prevent tissue injury, but also as… read more here.
Keywords: nrf2 promote; epithelial repair; promote epithelial; targeting nrf2 ... See more keywords
The therapeutic role of nutraceuticals targeting the Nrf2/HO-1 signaling pathway in liver cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.14357
Abstract: Liver cancer (L.C.) is the most common cause of cancer death in the United States and the fifth most common globally. The overexpression of nuclear factor E2 related factor 2 (Nrf2) and heme oxygenase 1… read more here.
Keywords: cancer; liver cancer; nrf2 signaling; pathway ... See more keywords
Abstract 2787: Targeting Nrf2 signaling pathway by Keap1-mediated degradation in acquired gemcitabine resistant pancreatic cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2787
Abstract: Redox status is a main indicator of cancer cell adaptation to chemotherapy. Nuclear factor erythroid 2-related factor 2 (Nrf2) is one of the crucial regulators of redox condition and can affected to drug resistance through… read more here.
Keywords: pancreatic cancer; keap1; gemcitabine resistant; targeting nrf2 ... See more keywords
Dapsone reduced cuprizone-induced demyelination via targeting Nrf2 and IKB in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.64993.14310
Abstract: Objective(s): Multiple Sclerosis (MS) is an inflammatory disorder wherein the myelin of nerve cells in the central nervous system is damaged. In the current study, we assessed the effect of Dapsone (DAP) on the improvement… read more here.
Keywords: cpz; nrf2 ikb; demyelination; targeting nrf2 ... See more keywords
MiR-93 inhibition ameliorates OGD/R induced cardiomyocyte apoptosis by targeting Nrf2.
Sign Up to like & getrecommendations! Published in 2017 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201712_13935
Abstract: OBJECTIVE To identify the expression changes of microRNA 93 (miR-93) in oxygen-glucose deprivation/reoxygenation (OGD/R) injury in cardiomyocytes and its mechanism of mediating OGD/R and inducing apoptosis. MATERIALS AND METHODS Primary cardiomyocytes were extracted and OGD/R… read more here.
Keywords: ogd induced; apoptosis; mir; targeting nrf2 ... See more keywords
MicroRNA-340-5p inhibits the malignant phenotypes of osteosarcoma by directly targeting NRF2 and deactivating the PI3K/AKT pathway.
Sign Up to like & getrecommendations! Published in 2021 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202105_25932
Abstract: OBJECTIVE The aim of the study was to examine the effects and potential mechanisms of miR-340-5p in Osteosarcoma (OS) progression. PATIENTS AND METHODS qRT-PCR was applied to detect expressions of miR-340-5p and NRF2 mRNA. MTT… read more here.
Keywords: pi3k akt; targeting nrf2; malignant phenotypes; mir 340 ... See more keywords
The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020236
Abstract: Redox balance is essential to maintain the body’s normal metabolism. Once disrupted, it may lead to various chronic diseases, such as diabetes, neurodegenerative diseases, cardiovascular diseases, inflammatory diseases, cancer, aging, etc. Oxidative stress can cause… read more here.
Keywords: phytochemicals chronic; oxidative stress; pathological processes; chronic diseases ... See more keywords
Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12020280
Abstract: Succinate dehydrogenase subunit B (SDHB) deficiency frequently occurs in cluster I pheochromocytomas and paragangliomas (PCPGs). SDHB-mutated PCPGs are characterized by alterations in the electron transport chain, metabolic reprogramming of the tricarboxylic cycle, and elevated levels… read more here.
Keywords: sdhb; sdhb mutated; targeting nrf2; nrf2 governed ... See more keywords