Novel biologics targeting the P2X7 ion channel.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.03.001
Abstract: Targeting the P2X7 ion channel, a danger sensor for extracellular nucleotides, improves outcomes in models of inflammation, cancer, and brain-diseases. Antibodies and nanobodies have been developed that antagonize or potentiate gating of P2X7. Their potential… read more here.
Keywords: p2x7; p2x7 ion; targeting p2x7; ion channel ... See more keywords
Targeting P2X7 receptors as a means for treating retinal disease.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.03.029
Abstract: Age-related macular degeneration and glaucoma are the commonest causes of irreversible vision loss in industrialized countries. The purine ATP is known to regulate a range of cellular functions in the retina via its action on… read more here.
Keywords: targeting p2x7; disease; p2x7 receptors; receptors means ... See more keywords