Structural insights into the mechanism of a novel protein targeting pathway in Gram‐negative bacteria
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12813
Abstract: Many nascent polypeptides synthesized in the cytoplasm are translocated across membranes via a specific ‘translocon’ composed of protein complexes. Recently, a novel targeting pathway for the outer membrane β‐barrel proteins (OMPs) in Gram‐negative bacteria was… read more here.
Keywords: protein; mechanism; gram negative; negative bacteria ... See more keywords
Targeting the PD-1/PD-L1 pathway in glioblastoma multiforme: Preclinical evidence and clinical interventions.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107403
Abstract: Glioblastoma multiforme (GBM), as one of the immunosuppressive and common intrinsic brain tumors in adults, remains an intractable malignancy to manage. Since the standard of care for treatment, which includes surgery and chemoradiation, has not… read more here.
Keywords: multiforme preclinical; glioblastoma multiforme; preclinical evidence; targeting pathway ... See more keywords
Navigations of the targeting pathway of nanomedicines toward tumor
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2110064
Abstract: ABSTRACT Introduction Nanomedicines (NMs) have emerged as a promising approach for revolutionizing cancer treatment outcomes, mainly due to their benefits in the tumor-targeted delivery of therapeutics. The preferential accumulation of NMs in tumors has been… read more here.
Keywords: targeting pathway; targeting mechanisms; navigations targeting; pathway nanomedicines ... See more keywords
Targeting the IL-2 pathway for the treatment of mucosal melanoma
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DOI: 10.1080/21678707.2022.2134776
Abstract: ABSTRACT Introduction Mucosal melanomas are rare and aggressive forms of cancer that have consistently eluded meaningful recovery with various anticancer therapies. Patients with unresectable mucosal melanomas have benefited from prolonged survival with the use of… read more here.
Keywords: targeting pathway; mucosal melanomas; treatment mucosal; pathway treatment ... See more keywords
Targeting the IL-1β pathway for cancer immunotherapy remodels the tumor microenvironment and enhances antitumor immune responses.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0290
Abstract: High levels of IL-1β can result in chronic inflammation, which in turn can promote tumor growth and metastasis. Inhibition of IL-1β could therefore be a promising therapeutic option in the treatment of cancer. Here, the… read more here.
Keywords: targeting pathway; pathway cancer; canakinumab gevokizumab; tumor microenvironment ... See more keywords