N-Acetyl Galactosamine Targeting: Paving the Way for Clinical Application of Nucleotide Medicines in Cardiovascular Diseases.
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DOI: 10.1161/atvbaha.121.316290
Abstract: While the promise of oligonucleotide therapeutics, such as (chemically modified) ASO (antisense oligonucleotides) and short interfering RNAs, is undisputed from their introduction onwards, their unfavorable pharmacokinetics and intrinsic capacity to mobilize innate immune responses, were… read more here.
Keywords: application; galactosamine targeting; acetyl galactosamine; targeting paving ... See more keywords