EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling
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DOI: 10.1126/sciadv.adj7251
Abstract: We recently developed a heterobifunctional approach [phosphorylation targeting chimeras (PhosTACs)] to achieve the targeted protein dephosphorylation (TPDephos). Here, we envisioned combining the inhibitory effects of receptor tyrosine kinase inhibitors (RTKIs) and the active dephosphorylation by… read more here.
Keywords: phostacs dual; egfr targeting; dephosphorylation; targeting phostacs ... See more keywords