Targeting Polymeric Nanoparticles to Specific Cell Populations in the Liver.
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DOI: 10.1021/acs.biochem.4c00712
Abstract: Nanoparticles (NPs) are beneficial for delivery of drugs in a variety of settings, serving to protect their cargo and allow for sustained release. Polymeric NPs offer several advantages as therapeutics carriers due to their tunable… read more here.
Keywords: targeting polymeric; nanoparticles specific; polymeric; specific cell ... See more keywords
Mitochondria-Targeting Polymeric Micelles for Intervertebral Disc Degeneration Alleviation via Coordinated Cascade Energetic Intervention.
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DOI: 10.1021/acsnano.5c13916
Abstract: Mitochondrial dysfunction plays a pivotal role in intervertebral disc degeneration (IVDD) by disrupting mitochondrial bioenergetic balance, which leads to impaired ATP synthesis, accumulation of ROS, degradation of the extracellular matrix, and degeneration of nucleus pulposus… read more here.
Keywords: targeting polymeric; disc degeneration; intervertebral disc; mitochondria targeting ... See more keywords
Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors.
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DOI: 10.2217/nnm-2022-0097
Abstract: Background: Serious side effects caused by paclitaxel formulation, containing toxic solubilizer Cremophor® EL, and its nonspecific accumulation greatly limit clinical paclitaxel application. Aim: To design paclitaxel-loaded copolymer of lactic and glycolic acids nanoparticles decorated with alpha-fetoprotein third domain… read more here.
Keywords: targeting polymeric; mediated targeting; polymeric nanoparticles; fetoprotein mediated ... See more keywords