Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy.
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DOI: 10.1016/j.canlet.2021.09.010
Abstract: Colorectal cancer (CRC) is one of the most common malignancies worldwide, and effective therapy remains a challenge. In this study, we take advantage of a drug repurposing strategy to screen small molecules with novel anticancer… read more here.
Keywords: suppresses colorectal; lomitapide; activation; targeting pp2a ... See more keywords