Novel hypoxia-targeting Pt(iv) prodrugs.
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DOI: 10.1039/c7cc01320e
Abstract: Novel Pt(iv) prodrugs targeting hypoxia inducible factor HIF-1α were prepared for evaluating their antitumor activity on hypoxic cancer cells for the first time. The resulting Pt(iv) prodrug exhibited effective inhibition on tumor growth in the… read more here.
Keywords: targeting prodrugs; novel hypoxia; hypoxia targeting;