Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex.
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DOI: 10.1021/acs.jmedchem.2c00467
Abstract: c-MYC is a key driver of tumorigenesis. Repressing the transcription of c-MYC by stabilizing the G-quadruplex (G4) structure with small molecules is a potential strategy for cancer therapy. Herein, we designed and synthesized 49 new… read more here.
Keywords: myc transcription; transcription; design synthesis; targeting promoter ... See more keywords