Abstract 2689: Targeting the proteasome pathway in dactinomycin resistant Wilms tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2689
Abstract: Nephroblastomas or Wilms tumors are the most common pediatric renal cancer. Across all cases, the 5-year overall survival is over 90%. This is largely in part due to brute-force, chemotherapy regimens such as dactinomycin (actD)… read more here.
Keywords: targeting proteasome; wilms; dactinomycin; tumor ... See more keywords
Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases
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DOI: 10.3390/ijms22126213
Abstract: The 26S proteasome is the principal protease for regulated intracellular proteolysis. This multi-subunit complex is also pivotal for clearance of harmful proteins that are produced throughout the lifetime of eukaryotes. Recent structural and kinetic studies… read more here.
Keywords: proteasome associated; proteasome; small molecule; targeting proteasome ... See more keywords