Targeting protein folding in N‐Myc‐driven medulloblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13395
Abstract: Selective targeting of N‐Myc‐driven Sonic hedgehog (SHH) medulloblastoma has been a challenge for many years and, despite decades of research, few targeted therapy opportunities exist. Recently, Kuzuoglu‐Ozturk et al. characterized the translatome of N‐Myc‐driven medulloblastoma… read more here.
Keywords: protein folding; targeting protein; folding myc; myc driven ... See more keywords
Targeting Protein Neddylation for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_18
Abstract: Neddylation is a posttranslational modification that conjugates a ubiquitin-like protein NEDD8 to substrate proteins. The best-characterized substrates of neddylation are the cullin subunits of cullin-RING E3 ubiquitin ligase complexes (CRLs). CRLs as the largest family… read more here.
Keywords: neddylation cancer; targeting protein; protein neddylation; neddylation ... See more keywords
Targeting G protein-coupled receptors in cancer therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in cancer research"
DOI: 10.1016/bs.acr.2019.11.002
Abstract: As basic research into GPCR signaling and its association with disease has come into fruition, greater clarity has emerged with regards to how these receptors may be amenable to therapeutic intervention. As a diverse group… read more here.
Keywords: research; targeting protein; protein coupled; receptors cancer ... See more keywords
Recent advance of peptide-based molecules and nonpeptidic small-molecules modulating PD-1/PD-L1 protein-protein interaction or targeting PD-L1 protein degradation.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113170
Abstract: Tumor immunotherapy has made great progress in recent years. In the tumor microenvironment, the binding of PD-1 and its ligand PD-L1 can promote tumor immune escape and tumor survival. Clinical studies have indicated that antibodies… read more here.
Keywords: protein; targeting protein; small molecules; peptide based ... See more keywords
Targeting Protein Pockets with Halogen Bonds: The Role of the Halogen Environment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00475
Abstract: Protein pockets that form a halogen bond (X-bond) with a halogenated ligand molecule simultaneously form other (mainly hydrophobic) interactions with the halogen atom that can be considered as its "X-bond environment" (XBenv). Most studies in… read more here.
Keywords: environment; targeting protein; pockets halogen; protein pockets ... See more keywords
AB0035 A physiological network of igg autoantibodies targeting g protein coupled receptors
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.4461
Abstract: Background Since the time when Paul Ehrlich conceived the term “horror autotoxicus”, autoantibodies have been associated with the development of autoimmune diseases. However, several works have recently shown the presence of autoantibodies in sera from… read more here.
Keywords: autoantibody; autoantibodies targeting; network; targeting protein ... See more keywords
Editorial: Computational drug discovery for targeting of protein-protein interfaces—Volume II
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1171597
Abstract: Protein-protein and protein-peptide recognition are among the most important processes that make signal transmission and transduction possible in a cell; they also play a role in cellular processes involving diseases. Theoretical approaches in the study… read more here.
Keywords: targeting protein; drug discovery; protein protein; protein ... See more keywords
Targeting Protein Kinase C in Glioblastoma Treatment
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9040381
Abstract: Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor and is associated with a poor prognosis. Despite the use of combined treatment approaches, recurrence is almost inevitable and survival longer than 14 or… read more here.
Keywords: glioblastoma; targeting protein; treatment; kinase glioblastoma ... See more keywords
Targeting Protein Synthesis in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12051298
Abstract: Under physiological conditions, protein synthesis controls cell growth and survival and is strictly regulated. Deregulation of protein synthesis is a frequent event in cancer. The majority of mutations found in colorectal cancer (CRC), including alterations… read more here.
Keywords: synthesis colorectal; targeting protein; colorectal cancer; protein synthesis ... See more keywords
Targeting Protein Kinase C for Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14051104
Abstract: Simple Summary The protein kinase C (PKC) family belongs to serine-threonine kinases and consists of several subtypes. Increasing evidence suggests that PKCs are critical players in carcinogenesis. Interestingly, PKCs exert both promotive and suppressive effects… read more here.
Keywords: targeting protein; cancer therapy; protein kinase; cancer ... See more keywords
Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073481
Abstract: Decreasing the levels of certain proteins has been shown to be important for controlling cancer but it is currently unknown whether proteins could potentially be targeted by the inhibiting of protein synthesis. Under this circumstance,… read more here.
Keywords: cholesterol metabolism; targeting protein; protein translation; cholesterol ... See more keywords