LAUSR

Targeting RAS signaling pathway as a potential therapeutic target in the treatment of colorectal cancer

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1 Published in 2018 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.25890

Abstract: The V‐Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is frequently dysregulated in colorectal cancer (CRC). It is involved in the modulation of several downstream effectors, that include: Raf/Mek/Erk, PI3K/Akt, RalGDS/p38MAPK, and Rac/Rho, and thereby… read more here.

Keywords: treatment; colorectal cancer; signaling pathway; targeting ras ... See more keywords

Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators

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0 Published in 2021 at "Acta Pharmaceutica Sinica B"

DOI: 10.1016/j.apsb.2021.02.014

Abstract: Abstract RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis,… read more here.

Keywords: phosphorylation; ras phosphorylation; phosphorylation cancer; targeting ras ... See more keywords

Targeting RAS in pediatric cancer: is it becoming a reality?

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1 Published in 2019 at "Current Opinion in Pediatrics"

DOI: 10.1097/mop.0000000000000856

Abstract: PURPOSE OF REVIEW The current review aims to highlight the frequency of RAS mutations in pediatric leukemias and solid tumors and to propose strategies for targeting oncogenic RAS in pediatric cancers. RECENT FINDINGS The three… read more here.

Keywords: targeting ras; ras mutations; cancer; pediatric cancer ... See more keywords

RAS, wanted dead or alive: Advances in targeting RAS mutant cancers

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2 Published in 2020 at "Science Signaling"

DOI: 10.1126/scisignal.aay6013

Abstract: New signaling insights level the playing field against the notoriously “undruggable” protein RAS. Oncogenic RAS proteins, which are mutated in approximately 24% of all human cancers, have earned a well-deserved reputation as being “undruggable.” However,… read more here.

Keywords: ras proteins; ras wanted; ras mutant; wanted dead ... See more keywords

Abstract IA18: Targeting K-Ras directly

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1 Published in 2020 at "Molecular Cancer Research"

DOI: 10.1158/1557-3125.ras18-ia18

Abstract: Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer and are generally associated with poor response to standard therapies. Efforts to directly target this oncogene have faced… read more here.

Keywords: abstract ia18; targeting ras; ia18 targeting; ras directly ... See more keywords

Abstract IA14: Targeting Ras

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2 Published in 2017 at "Clinical Cancer Research"

DOI: 10.1158/1557-3265.pmccavuln16-ia14

Abstract: We are exploring multiple ways of targeting Ras proteins and Ras-driven cancers. We have identified compounds that covalently bind to cysteine-185 on K-Ras 4B, and to the G-domain of K-Ras 4A and 4B. We are… read more here.

Keywords: medicine; ras abstract; ia14 targeting; abstract ia14 ... See more keywords

Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors

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1 Published in 2022 at "PLoS Computational Biology"

DOI: 10.1371/journal.pcbi.1009962

Abstract: K-Ras activating mutations are significantly associated with tumor progression and aggressive metastatic behavior in various human cancers including pancreatic cancer. So far, despite a large number of concerted efforts, targeting of mutant-type K-Ras has not… read more here.

Keywords: molecule inhibitors; small molecule; peptide small; molecule ... See more keywords