Targeting RNA in mammalian systems with small molecules
Sign Up to like & getrecommendations! Published in 2018 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1477
Abstract: The recognition of RNA functions beyond canonical protein synthesis has challenged the central dogma of molecular biology. Indeed, RNA is now known to directly regulate many important cellular processes, including transcription, splicing, translation, and epigenetic… read more here.
Keywords: targeting rna; mammalian systems; rna; small molecules ... See more keywords
It's Not What You Say But How You Say It: Targeting RNA Methylation in AML.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.027
Abstract: In this month's issue of Cancer Cell, Su et al. (2020) describe two small-molecule inhibitors of the RNA demethylase FTO that demonstrate significant anti-tumor effects in various models of acute myeloid leukemia. read more here.
Keywords: targeting rna; rna methylation; say targeting; methylation aml ... See more keywords
Strategies for targeting RNA with small molecule drugs
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2111414
Abstract: ABSTRACT Introduction Historically, therapeutic treatment of disease has been restricted to targeting proteins. Of the approximately 20,000 translated human proteins, approximately 1600 are associated with diseases. Strikingly, less than 15% of disease-associated proteins are predicted… read more here.
Keywords: small molecule; targeting rna; molecule; molecule drugs ... See more keywords
Targeting RNA with small molecules a safety perspective.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16027
Abstract: RNA is a major player in cellular function and consequently can drive a number of disease pathologies. Over the past several years, small molecule-RNA targeting (smRNA) has developed into a promising drug discovery approach. Numerous… read more here.
Keywords: safety; targeting rna; rna; rna small ... See more keywords
Abstract SY04-01: Understanding and targeting RNA splicing in breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-sy04-01
Abstract: Upregulation of SR proteins, a family of 14 essential splicing factors (SFs), often occurs in solid tumors, including in breast, and promotes mammary cell transformation and metastasis in breast cancer models. SR protein alterations often… read more here.
Keywords: rna splicing; targeting rna; breast; breast cancer ... See more keywords
Abstract 4731: Therapeutic targeting of RNA splicing through inhibition of protein arginine methylation
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-4731
Abstract: Mutations in RNA splicing factors commonly occur in myeloid leukemia and solid tumors. These mutations occur in a heterozygous manner and confer dependency on the wild-type allele. Studies have shown that splicing factor mutant cancers… read more here.
Keywords: protein arginine; therapeutic targeting; inhibition protein; targeting rna ... See more keywords
Targeting RNA with small molecules: lessons learned from Xist RNA
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079523.122
Abstract: Although more than 98% of the human genome is noncoding, nearly all drugs on the market target one of about 700 disease-related proteins. However, an increasing number of diseases are now being attributed to noncoding… read more here.
Keywords: rna targeting; targeting rna; lessons learned; rna ... See more keywords
Targeting RNA G‐quadruplexes as new treatment strategy for C9orf72 ALS/FTD
Sign Up to like & getrecommendations! Published in 2018 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201708572
Abstract: The recent discovery of a pathogenic expansion of a (GGGGCC)n repeat in the C9orf72 gene in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) led to a burst of mechanistic discoveries. In this issue, Simone… read more here.
Keywords: targeting rna; rna quadruplexes; strategy c9orf72; treatment strategy ... See more keywords
Targeting the RNA-Binding Protein HuR as Potential Thera-Peutic Approach for Neurological Disorders: Focus on Amyo-Trophic Lateral Sclerosis (ALS), Spinal Muscle Atrophy (SMA) and Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910394
Abstract: The importance of precise co- and post-transcriptional processing of RNA in the regulation of gene expression has become increasingly clear. RNA-binding proteins (RBPs) are a class of proteins that bind single- or double-chain RNA, with… read more here.
Keywords: targeting rna; sclerosis; protein hur; hur potential ... See more keywords