MiR-539-3p Alleviates Apoptosis and Extracellular Matrix Degradation in Chondrocytes of Childhood-Onset Osteoarthritis by Targeting RUNX2.
Sign Up to like & getrecommendations! Published in 2024 at "Physiological research"
DOI: 10.33549/physiolres.935291
Abstract: Recent research has identified that miR-539-3p impedes chondrogenic differentiation, yet its specific role and underlying mechanisms in childhood-onset osteoarthritis (OA) remain unclear. This study found that miR-539-3p levels were considerably lower in cartilage samples derived… read more here.
Keywords: matrix; degradation chondrocytes; targeting runx2; mir 539 ... See more keywords
miR-204-5p inhibits the occurrence and development of osteoarthritis by targeting Runx2
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DOI: 10.3892/ijmm.2018.3811
Abstract: One of the hallmarks of osteoarthritis (OA) development is endochondral ossification, in which Runt-related transcription factor-2 (Runx2) is aberrantly expressed. Runx2 was previously identified to be regulated by microRNA-204-5p (miR-204-5p). The aim of the present… read more here.
Keywords: targeting runx2; runx2; expression; mir 204 ... See more keywords