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Published in 2020 at "Chemmedchem"
DOI: 10.1002/cmdc.202000259
Abstract: Coronavirus disease 2019 (COVID‐19) has spread out as a pandemic threat affecting over 2 million people. The infectious process initiates via binding of SARS‐CoV‐2 Spike (S) glycoprotein to host angiotensin‐converting enzyme 2 (ACE2). The interaction…
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Keywords:
cov rbd;
targeting sars;
supervised computational;
rbd interface ... See more keywords
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Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01005
Abstract: The viral main protease is one of the most attractive targets among all key enzymes involved in the SARS-CoV-2 life cycle. Covalent inhibition of the cysteine145 of SARS-CoV-2 MPRO with selective antiviral drugs will arrest…
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Keywords:
cov mpro;
targeting sars;
main protease;
covalent ... See more keywords
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Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00312
Abstract: SARS-CoV-2 remains a significant burden on human health. Several lines of evidence suggest that surveillance of sewage and waste can provide an early warning sign for COVID-19 recurrence in a community. In support, SARS-CoV-2 traces…
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Keywords:
source antiviral;
source;
targeting sars;
covid ... See more keywords
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Published in 2021 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.0c00815
Abstract: Two proteases produced by the SARS-CoV-2 virus, the main protease and papain-like protease, are essential for viral replication and have become the focus of drug development programs for treatment of COVID-19. We screened a highly…
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Keywords:
protease;
targeting sars;
covid;
challenges targeting ... See more keywords
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Published in 2022 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.2c00359
Abstract: Essential viral enzymes have been successfully targeted to combat the diseases caused by emerging pathogenic RNA viruses (e.g., viral RNA-dependent RNA polymerase). Because of the conserved nature of such viral enzymes, therapeutics targeting these enzymes…
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Keywords:
mtase;
cov genome;
rna;
targeting sars ... See more keywords
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Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18159-4
Abstract: The novel highly transmissible human coronavirus SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Thus far, there is no approved therapeutic drug specifically targeting this emerging virus. Here we report the isolation and characterization…
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Keywords:
panel human;
targeting sars;
human neutralizing;
neutralizing mabs ... See more keywords
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Published in 2020 at "Epigenomics"
DOI: 10.2217/epi-2020-0154
Abstract: SARS-CoV-2, a betacoronavirus is the infectious viral agent causing the current pandemic of COVID-19. The disease causes acute respiratory distress syndrome, an inflammatory response which is the major cause of mortality of this disease. The…
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Keywords:
polycomb inhibitors;
using polycomb;
targeting sars;
cov using ... See more keywords
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Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2021.819165
Abstract: The emergence of severe acute respiratory syndrome (SARS-CoV-2) in 2019 marked the third occurrence of a highly pathogenic coronavirus in the human population since 2003. As the death toll surpasses 5 million globally and economic…
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Keywords:
antiviral development;
proteases covid;
targeting sars;
sars cov ... See more keywords
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Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.708665
Abstract: It is clear that COVID-19 is more than a pneumonia and is associated with a coagulopathy and multi-organ failure. While the use of anti-coagulants does reduce the incidence of pulmonary emboli, it does not help…
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Keywords:
targeting sars;
platelet interactions;
thrombosis;
cov platelet ... See more keywords
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Published in 2022 at "Viruses"
DOI: 10.3390/v14020443
Abstract: In early 2020, the COVID-19 pandemic sparked a global crisis that continues to pose a serious threat to human health and the economy. Further advancement in research is necessary and requires the availability of quality…
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Keywords:
collection monoclonal;
sars cov;
targeting sars;
monoclonal antibodies ... See more keywords
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Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.12929
Abstract: The spread of SARS-CoV-2, the causative agent for COVID-19, has led to a global and deadly pandemic. To date, few drugs have been approved for treating SARS-CoV-2 infections. In this study, a structure-based approach was…
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Keywords:
drug discovery;
targeting sars;
main protease;
discovery targeting ... See more keywords