MicroRNA-212 activates hepatic stellate cells and promotes liver fibrosis via targeting SMAD7.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.019
Abstract: There has been an increasing number of researches about microRNAs (miRNAs) in the progression of liver fibrosis from the point of their comprehensive functions in regulating the activation of hepatic stellate cells (HSCs). Among them,… read more here.
Keywords: liver fibrosis; mir 212; targeting smad7; hepatic stellate ... See more keywords
Targeting of Smad7 in Mesenchymal Cells Does Not Exacerbate Fibrosis During Experimental Chronic Pancreatitis
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DOI: 10.1097/mpa.0000000000001951
Abstract: Objectives Transforming growth factor-β (TGF-β)–mediated accumulation of extracellular matrix proteins such as collagen I is a common feature of fibrosis. Pancreatic stellate cells play an integral role in the pathogenesis of pancreatitis, and their profibrotic… read more here.
Keywords: pancreatitis; targeting smad7; chronic pancreatitis; fibrosis ... See more keywords