Bioactive modulators targeting STING adaptor in cGAS-STING pathway.
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DOI: 10.1016/j.drudis.2019.11.007
Abstract: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-pathway triggers innate immune responses by recognizing cytosolic DNA. Recent studies revealed that STING adaptor associates with various diseases, and several modulators targeting STING have been identified… read more here.
Keywords: cgas; sting pathway; targeting sting; sting adaptor ... See more keywords
Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines.
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DOI: 10.1039/c8cc04860f
Abstract: Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2'-OH of CDG) strategies for activating the STING pathway. CDG in both strategies behaved as a potent immunostimulant and… read more here.
Keywords: sting cyclic; cyclic gmp; targeting sting; cancer vaccines ... See more keywords