Bioactive modulators targeting STING adaptor in cGAS-STING pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.11.007
Abstract: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-pathway triggers innate immune responses by recognizing cytosolic DNA. Recent studies revealed that STING adaptor associates with various diseases, and several modulators targeting STING have been identified… read more here.
Keywords: cgas; sting pathway; targeting sting; sting adaptor ... See more keywords
Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines.
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DOI: 10.1039/c8cc04860f
Abstract: Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2'-OH of CDG) strategies for activating the STING pathway. CDG in both strategies behaved as a potent immunostimulant and… read more here.
Keywords: sting cyclic; cyclic gmp; targeting sting; cancer vaccines ... See more keywords
IMMU-54. THERAPEUTIC TARGETING OF STING IN MENINGIOMAS
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0646
Abstract: Up to one-quarter of meningiomas recur within five years of resection; however, there are currently no established adjuvant therapies for lesions that are intractable to surgery and radiation. To identify novel treatment approaches, scRNA-sequencing datasets… read more here.
Keywords: therapeutic targeting; immu therapeutic; meningiomas; targeting sting ... See more keywords