A comparison of prostate tumor targeting strategies using magnetic resonance imaging‐targeted, transrectal ultrasound‐guided fusion biopsy
Sign Up to like & getrecommendations! Published in 2018 at "Medical Physics"
DOI: 10.1002/mp.12769
Abstract: PURPOSE Magnetic resonance imaging (MRI)-targeted, three-dimensional (3D) transrectal ultrasound (TRUS)-guided prostate biopsy aims to reduce the 21-47% false-negative rate of clinical two-dimensional (2D) TRUS-guided systematic biopsy, but continues to yield false-negative results. This may be… read more here.
Keywords: prostate; biopsy; probability; error ... See more keywords
Nucleolin-based targeting strategies for cancer therapy: from targeted drug delivery to cytotoxic ligands.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.06.018
Abstract: Cancer is currently the second leading cause of death worldwide and current therapeutic approaches remain ineffective in several cases. Therefore, there is a need to develop more efficacious therapeutic agents, especially for subtypes of cancer… read more here.
Keywords: nucleolin based; based targeting; drug; targeting strategies ... See more keywords
Drug targeting strategies into the brain for treating neurological diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2018.10.015
Abstract: Brain specific drug delivery is one of the most interesting and challenging areas of research. The blood-brain barrier separates the brain from blood and acts as a barrier to protect the brain from microorganisms, neurotoxins… read more here.
Keywords: treating neurological; targeting strategies; brain treating; drug targeting ... See more keywords
Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00188
Abstract: Important steps in embryonic development are governed by the Hedgehog (Hh) signaling pathway, an evolutionary conserved signal transduction cascade. However, Hh activity not only is crucial during embryo formation but also is involved in adult… read more here.
Keywords: update pharmacological; hedgehog update; inhibiting hedgehog; targeting strategies ... See more keywords
Targeting the Central Nervous System (CNS): A Review of Rabies Virus-Targeting Strategies.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00158
Abstract: The transport of drugs across the blood-brain barrier is challenging. The use of peptide sequences derived from viruses with a central nervous system (CNS) tropism is one elegant option. A prominent example is the rabies… read more here.
Keywords: rabies virus; nervous system; central nervous; system cns ... See more keywords
Relational dynamics of protest and protest policing: strategic interaction and the coevolution of targeting strategies
Sign Up to like & getrecommendations! Published in 2018 at "Policing and Society"
DOI: 10.1080/10439463.2016.1262366
Abstract: ABSTRACT This article investigates the relational dynamics of lawful and unlawful protest in the wake of the British Stop Huntingdon Animal Cruelty (SHAC) campaign, and the plural policing efforts by public and private actors it… read more here.
Keywords: protest; strategic interaction; coevolution targeting; targeting strategies ... See more keywords
The molecular mechanisms and targeting strategies of transcription factors in cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2137020
Abstract: ABSTRACT Introduction Cholangiocarcinoma consists of a cluster of malignant biliary tumors that tend to have a poor prognosis, ranking as the second most prevalent type of liver cancer, and their incidence rate has increased globally… read more here.
Keywords: targeting strategies; transcription; strategies transcription; transcription factors ... See more keywords
Targeting Strategies for Enhancing Paclitaxel Specificity in Chemotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.626910
Abstract: Paclitaxel (PTX) has been used for cancer treatment for decades and has become one of the most successful chemotherapeutics in the clinic and financially. However, serious problems with its use still exist, owing to its… read more here.
Keywords: specificity chemotherapy; paclitaxel specificity; targeting strategies; strategies enhancing ... See more keywords
LRRK2 Targeting Strategies as Potential Treatment of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11081101
Abstract: Parkinson’s Disease (PD) affects millions of people worldwide with no cure to halt the progress of the disease. Leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause of PD and, as such, LRRK2… read more here.
Keywords: strategies potential; disease; lrrk2 targeting; targeting strategies ... See more keywords