Metabolic targeting synergizes with MAPK inhibition and delays drug resistance in melanoma.
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DOI: 10.1016/j.canlet.2018.11.018
Abstract: Tumors, including melanomas, frequently show an accelerated glucose metabolism. Mutations in the v-Raf murine sarcoma viral oncogene homolog B (BRAF), detected in about 50% of all melanomas, result in further enhancement of glycolysis. Therefore anti-metabolic… read more here.
Keywords: melanoma; targeting synergizes; metabolic targeting; resistance ... See more keywords