Folic acid rescues corticosteroid‐induced vertebral malformations in chick embryos through targeting TGF‐β signaling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29707
Abstract: Folic acid (FA) is routinely supplemented in the food of pregnant women or women planning a pregnancy, but whether FA exerts a positive effect on preventing fetal bone malformation remains obscure. In this study, we… read more here.
Keywords: folic acid; dex; chick embryos; targeting tgf ... See more keywords
Targeting TGFβ signal transduction for cancer therapy
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00436-9
Abstract: Transforming growth factor-β (TGFβ) family members are structurally and functionally related cytokines that have diverse effects on the regulation of cell fate during embryonic development and in the maintenance of adult tissue homeostasis. Dysregulation of… read more here.
Keywords: therapy; targeting tgf; cancer; signal transduction ... See more keywords
Targeting TGF-β signal transduction for fibrosis and cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer"
DOI: 10.1186/s12943-022-01569-x
Abstract: Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune supervision, tissue repair, and adult homeostasis. The role of TGF-β in fibrosis and cancer is… read more here.
Keywords: targeting tgf; tgf; cancer; tgf signal ... See more keywords
M7824 (MSB0011359C), a bifunctional fusion protein targeting PD-L1 and TGF-β, in Asian patients with pretreated recurrent or refractory gastric cancer: Preliminary results from a phase I trial.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.100
Abstract: 100Background: Inhibiting the transforming growth factor β (TGF-β) pathway, which plays a key role in tumor immunosuppression, may enhance the response to programmed death 1/programmed death ligand... read more here.
Keywords: m7824 msb0011359c; protein targeting; targeting tgf; msb0011359c bifunctional ... See more keywords
Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10071075
Abstract: Rescue of cognitive function represents an unmet need in the treatment of neurodegenerative disorders such as Alzheimer’s disease (AD). Nutraceuticals deliver a concentrated form of a presumed bioactive(s) agent(s) that can improve cognitive function alone… read more here.
Keywords: targeting tgf; tgf; improving cognition; cognitive function ... See more keywords
An In-Silico Identification of Potential Flavonoids against Kidney Fibrosis Targeting TGFβR-1
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12111764
Abstract: Fibrosis is a hallmark of progressive kidney diseases. The overexpression of profibrotic cytokine, namely transforming growth factor β (TGF-β) due to excessive inflammation and tissue damage, induces kidney fibrosis. The inhibition of TGF-β signaling is… read more here.
Keywords: kidney fibrosis; silico identification; fibrosis; targeting tgf ... See more keywords
Medicinal Chemistry Strategies in Targeting TGF-βR1 Kinase Domain: Unveiling Insights into Inhibitor Structure–Activity Relationship (SAR)
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceuticals"
DOI: 10.3390/ph18050716
Abstract: The transforming growth factor-β (TGF-β) signaling pathway is involved in various cellular functions, including immunological response, extracellular matrix formation, differentiation, growth and development, and cell cycle regulation. The TGF β receptor type 1 (TGF-βR1) has… read more here.
Keywords: targeting tgf; chemistry; tgf signaling; tgf kinase ... See more keywords
Unraveling the Exosome-miR-133a Axis: Targeting TGF-β Signaling via WJ-MSC-Derived Exosomes for Anti-Fibrotic Therapy in Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Iranian Biomedical Journal"
DOI: 10.61186/ibj.4357
Abstract: Background: One of the primary drivers of liver fibrosis is the excessive accumulation of ECM, primarily caused by the over-proliferation of HSCs. The activation of HSCs by TGF-β has a critical role in initiating fibrosis.… read more here.
Keywords: targeting tgf; tgf signaling; fibrosis; mir 133a ... See more keywords